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mmp14b matrix metallopeptidase 14b (membrane-inserted) [ Danio rerio (zebrafish) ]

Gene ID: 566945, updated on 19-Jan-2025

Summary

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Official Symbol
mmp14bprovided by ZNC
Official Full Name
matrix metallopeptidase 14b (membrane-inserted)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030901-2
See related
Ensembl:ENSDARG00000008388 AllianceGenome:ZFIN:ZDB-GENE-030901-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MT-MMPbeta
Summary
Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mmp14b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38161267..38183641)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38178825..38201129)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 110 Neighboring gene spalt-like transcription factor 2 Neighboring gene apoptotic chromatin condensation inducer 1a Neighboring gene si:ch211-14a17.11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An injury-responsive mmp14b enhancer is required for heart regeneration. Zlatanova I, et al. Sci Adv, 2023 Dec. PMID 38019918, Free PMC Article
  2. The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos. Zhang J, et al. Matrix Biol, 2003 May. PMID 12853038
  3. Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype. de Vos IJHM, et al. Hum Mol Genet, 2018 Aug 15. PMID 29741626, Free PMC Article
  4. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Bai S, et al. Matrix Biol, 2005 Jun. PMID 15935631
  5. Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage. Yang R, et al. Dis Model Mech, 2017 Mar 1. PMID 28153846, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An injury-responsive mmp14b enhancer is required for heart regeneration.
    Title: An injury-responsive mmp14b enhancer is required for heart regeneration.
  2. Data indicate Mmp14a-dependent retinal defects lead to microphthalmia; Mmp14b, on the contrary, does not appear to alter retinal neurogenesis.
    Title: Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development.
  3. Data suggest that the MT1-MMP-PTK7 axis plays an important role in normal embryogenesis.
    Title: The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
  4. Data show that Mmp14 is required for proper cell polarity underlying the directed migration of mesodermal cells during gastrulation, and identify a genetic interaction between mmp14 and non-canonical Wnt signaling.
    Title: Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling.
  5. MT-MMPalpha and beta were expressed through at least the first 72 h of development and this expression was targeted to the cell surface
    Title: The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endochondral ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intramembranous ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect lamellipodium organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect lamellipodium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect regulation of extracellular matrix assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect regulation of extracellular matrix assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-14b
Names
matrix metalloproteinase 14 (membrane-inserted) beta
matrix metalloproteinase 14b (membrane-inserted)
zMT-MMP-beta
NP_919395.1
XP_005171367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194414.1 → NP_919395.1  matrix metalloproteinase-14b precursor

    See identical proteins and their annotated locations for NP_919395.1

    Status: PROVISIONAL

    Source sequence(s)
    AY324197
    UniProtKB/TrEMBL
    Q7T2J1
    Related
    ENSDARP00000044263.5, ENSDART00000044264.6
    Conserved Domains (5) summary
    cd00094
    Location:311 → 503
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:111 → 277
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:111 → 277
    Peptidase_M10; Matrixin
    pfam01471
    Location:29 → 81
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:563 → 621
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    38161267..38183641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171310.5 → XP_005171367.1  matrix metalloproteinase-14b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIQ9, B0R0I1
    Conserved Domains (5) summary
    cd00094
    Location:311 → 503
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:111 → 277
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:111 → 277
    Peptidase_M10; Matrixin
    pfam01471
    Location:29 → 81
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:563 → 621
    DUF3377; Domain of unknown function (DUF3377)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    206698..227474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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