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cdt1 chromatin licensing and DNA replication factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 566787, updated on 9-Dec-2024

Summary

Official Symbol
cdt1provided by ZNC
Official Full Name
chromatin licensing and DNA replication factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070111-1
See related
Ensembl:ENSDARG00000051854 AllianceGenome:ZFIN:ZDB-GENE-070111-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc37h07; im:7158083; wu:fc37h07; wu:fi38h09
Summary
Predicted to enable DNA binding activity and DNA polymerase binding activity. Acts upstream of or within mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; mesoderm; proliferative region; pronephric duct; and somite. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See cdt1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (55518519..55530662)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (55217099..55229335)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 homolog (S. pombe) Neighboring gene piezo type mechanosensitive ion channel component 1 (Er blood group) Neighboring gene adenine phosphoribosyltransferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene trafficking protein particle complex subunit 2L

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA replication preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DNA replication factor Cdt1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    55518519..55530662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_690072.9XP_695164.3  DNA replication factor Cdt1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7T7X4, E7F2R5
    Related
    ENSDARP00000089247.4, ENSDART00000098476.6
    Conserved Domains (2) summary
    cd08767
    Location:544669
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
    pfam08839
    Location:321484
    CDT1; DNA replication factor CDT1 like
  2. XM_017357105.3XP_017212594.1  DNA replication factor Cdt1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YZJ1