fsd1 fibronectin type III and SPRY domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fsd1provided by ZNC
Official Full Name: fibronectin type III and SPRY domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-218
See related: Ensembl:ENSDARG00000062017 AllianceGenome:ZFIN:ZDB-GENE-060503-218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-232d19.3
Summary: Predicted to enable microtubule binding activity. Acts upstream of or within with a positive effect on cilium assembly. Predicted to be located in several cellular components, including centrosome; cleavage furrow; and nucleus. Predicted to be active in microtubule. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (18624658..18647347)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (18593664..18617147)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibronectin type III and SPRY domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045117.3 → NP_001038582.1 fibronectin type III and SPRY domain-containing protein 1

See identical proteins and their annotated locations for NP_001038582.1

Status: VALIDATED

Source sequence(s)

BC162320, BX247907

UniProtKB/Swiss-Prot

Q1LY10

UniProtKB/TrEMBL

B3DG96

Related

ENSDARP00000083574.5, ENSDART00000089141.5

Conserved Domains (3) summary

cd00063
Location:165 → 265

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12901
Location:270 → 475

SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

cl23765
Location:4 → 127

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits