tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tab3provided by ZNC
Official Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-408
See related: Ensembl:ENSDARG00000062063 AllianceGenome:ZFIN:ZDB-GENE-060503-408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: map3k7ip3; map3k7ip3l; si:dkey-30h22.6; si:ch211-232d19.8
Summary: Predicted to enable kinase activity; metal ion binding activity; and ubiquitin binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within phosphorylation. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (18545506..18562979)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (18509827..18527273)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Names: TAK1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045105.1 → NP_001038570.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

See identical proteins and their annotated locations for NP_001038570.1

Status: PROVISIONAL

Source sequence(s)

BX247907

UniProtKB/TrEMBL

A0A8M6YZT9, A4IFZ0, Q1LY04

Related

ENSDARP00000083707.5, ENSDART00000089274.7

Conserved Domains (3) summary

smart00547
Location:547 → 570

ZnF_RBZ; Zinc finger domain

cd14362
Location:10 → 51

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

sd00029
Location:548 → 567

zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

18545506..18562979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478287.2 → XP_021333962.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

UniProtKB/TrEMBL

A0A8M6YZT9, A0A8M9PQZ1, A4IFZ0

Related

ENSDARP00000148312.1, ENSDART00000191398.1

Conserved Domains (4) summary

smart00547
Location:523 → 546

ZnF_RBZ; Zinc finger domain

cd14362
Location:10 → 51

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

sd00029
Location:524 → 543

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cl27975
Location:112 → 423

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)