fmn2b formin 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fmn2bprovided by ZNC
Official Full Name: formin 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080225-35
See related: Ensembl:ENSDARG00000061778 AllianceGenome:ZFIN:ZDB-GENE-080225-35
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7158925
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in formin-nucleated actin cable assembly. Predicted to act upstream of or within actin nucleation. Predicted to be located in actin filament. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in central nervous system and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 47. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (47446253..47541294)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (47448359..47543422)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

The Formin Fmn2b Is Required for the Development of an Excitatory Interneuron Module in the Zebrafish Acoustic Startle Circuit.
Title: The Formin Fmn2b Is Required for the Development of an Excitatory Interneuron Module in the Zebrafish Acoustic Startle Circuit.
Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones.
Title: Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in formin-nucleated actin cable assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info