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c4 complement component 4 [ Danio rerio (zebrafish) ]

Gene ID: 566261, updated on 9-Dec-2024

Summary

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Official Symbol
c4provided by ZNC
Official Full Name
complement component 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5697
See related
Ensembl:ENSDARG00000015065 AllianceGenome:ZFIN:ZDB-GENE-030131-5697
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi14a03
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in several cellular components, including axon; dendrite; and synapse. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)); C4B (complement C4B (Chido/Rodgers blood group)); and C4B_2 (complement component 4B (Chido/Rodgers blood group), copy 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
chromosome: 15
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (32353475..32383452, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32494101..32525477, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor interacting protein 2a Neighboring gene FH2 domain containing 4 Neighboring gene tripartite motif containing 3a Neighboring gene si:ch211-162k9.5 Neighboring gene si:dkey-285b23.4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fish complement C4 gene evolution and gene/protein regulatory network analyses and simulated stereo conformation of C4-MASP-2 protein complex. Li L, et al. Fish Shellfish Immunol, 2020 Dec. PMID 32980531
  2. Linkage relationships of genes coding for alpha2-macroglobulin, C3 and C4 in the zebrafish: implications for the evolution of the complement and Mhc systems. Samonte IE, et al. Scand J Immunol, 2002 Oct. PMID 12234255
  3. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Wang Z, et al. Fish Shellfish Immunol, 2008 Sep. PMID 18657447
  4. An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Pereiro P, et al. Front Immunol, 2022. PMID 36713462, Free PMC Article
  5. A Temporal Map of Gene Expression Pattern During Zebrafish Liver Regeneration. Jagtap U, et al. Zebrafish, 2020 Feb. PMID 31770088

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C4-B
Names
complement component 4A
complement component 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    32353475..32383452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466464.2 → XP_021322139.1  complement C4-B isoform X2

    UniProtKB/TrEMBL
    A0A8M9PCH5
    Conserved Domains (7) summary
    cd00017
    Location:675 → 731
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:977 → 1276
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:766 → 856
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128 → 220
    A2M_N; MG2 domain
    pfam07677
    Location:1414 → 1502
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:457 → 597
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1520 → 1678
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  2. XM_005157372.5 → XP_005157429.1  complement C4-B isoform X1

    UniProtKB/TrEMBL
    A0A8M2B3G6, F1Q4X5
    Related
    ENSDARP00000031658.5, ENSDART00000028349.8
    Conserved Domains (8) summary
    cd00017
    Location:675 → 731
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:977 → 1276
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03584
    Location:1540 → 1698
    NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
    pfam00207
    Location:766 → 856
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128 → 220
    A2M_N; MG2 domain
    pfam07677
    Location:1434 → 1522
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1032 → 1278
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:459 → 595
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein Strain
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