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adam10a ADAM metallopeptidase domain 10a [ Danio rerio (zebrafish) ]

Gene ID: 566044, updated on 9-Dec-2024

Summary

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Official Symbol
adam10aprovided by ZNC
Official Full Name
ADAM metallopeptidase domain 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040917-2
See related
Ensembl:ENSDARG00000053468 AllianceGenome:ZFIN:ZDB-GENE-040917-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
adam10; wu:fc03d12
Summary
Predicted to enable metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See adam10a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30409071..30492030, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30137916..30220894, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene aquaporin 9b Neighboring gene lipase, hepatic a Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene SAFB-like, transcription modulator Neighboring gene ring finger protein 111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
  2. The N-glycome regulates the endothelial-to-hematopoietic transition. Kasper DM, et al. Science, 2020 Dec 4. PMID 33273096, Free PMC Article
  3. A novel perivascular cell population in the zebrafish brain. Venero Galanternik M, et al. Elife, 2017 Apr 11. PMID 28395729, Free PMC Article
  4. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
  5. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain 10a
NP_001152786.2
NP_001417916.1
XP_005168954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159314.2 → NP_001152786.2  disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL935053, BX957301
    UniProtKB/TrEMBL
    A0A0R4IVX1, A0A8M1NSP3
    Related
    ENSDARP00000141214.2, ENSDART00000162705.2

  2. NM_001430987.1 → NP_001417916.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL935053, BX957301
    UniProtKB/TrEMBL
    A0A0R4IVX1, A0A1D5NT24, A0A8M1NSP3, A0A8M2BG63
    Related
    ENSDARP00000142998.1, ENSDART00000173954.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    30409071..30492030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168897.5 → XP_005168954.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IVX1, A0A8M1NSP3, A0A8M2BGT1, F1RA88
    Related
    ENSDARP00000090413.6, ENSDART00000099639.8
    Conserved Domains (4) summary
    smart00050
    Location:472 → 558
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:226 → 465
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:54 → 151
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:246 → 451
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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