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cdc42bpab CDC42 binding protein kinase alpha (DMPK-like) b [ Danio rerio (zebrafish) ]

Gene ID: 566003, updated on 4-Jan-2025

Summary

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Official Symbol
cdc42bpabprovided by ZNC
Official Full Name
CDC42 binding protein kinase alpha (DMPK-like) bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080219-17
See related
Ensembl:ENSDARG00000016464 AllianceGenome:ZFIN:ZDB-GENE-080219-17
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb82d10; wu:fb82d10; zgc:174985; si:ch211-89p3.3
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in lamellipodium. Predicted to be active in actomyosin and cytoplasm. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cdc42bpab in Genome Data Viewer
Location:
chromosome: 20
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (35085883..35206278)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35182065..35303108)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein Ub Neighboring gene lefty1 Neighboring gene F-box protein 16 Neighboring gene frizzled class receptor 3a Neighboring gene family with sequence similarity 49 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC174985

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK alpha
NP_001038559.1
XP_005160808.1
XP_021324156.1
XP_021324160.1
XP_021324161.1
XP_068071617.1
XP_068071618.1
XP_068071619.1
XP_068071620.1
XP_068071621.1
XP_068071622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045094.1 → NP_001038559.1  serine/threonine-protein kinase MRCK alpha

    Status: PROVISIONAL

    Source sequence(s)
    BX470246, BX511007
    UniProtKB/TrEMBL
    A0A8M1N9Z6, A0A8M6YU74, Q5TZ37
    Related
    ENSDARP00000040455.6, ENSDART00000040456.9
    Conserved Domains (8) summary
    pfam08826
    Location:880 → 940
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:506 → 781
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:1058 → 1192
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:998 → 1048
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1218 → 1480
    CNH; CNH domain
    pfam15796
    Location:528 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    35085883..35206278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215516.1 → XP_068071617.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M9P2P6

  2. XM_068215519.1 → XP_068071620.1  serine/threonine-protein kinase MRCK alpha isoform X5

    UniProtKB/TrEMBL
    A0A8M6YU74

  3. XM_068215517.1 → XP_068071618.1  serine/threonine-protein kinase MRCK alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M9PBV1

  4. XM_068215520.1 → XP_068071621.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    A0A8M6YU74

  5. XM_021468481.2 → XP_021324156.1  serine/threonine-protein kinase MRCK alpha isoform X4

    UniProtKB/TrEMBL
    A0A8M9P2P6, A0A8M9PPH2
    Conserved Domains (7) summary
    pfam08826
    Location:887 → 947
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:438 → 945
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1117 → 1251
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 419
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1057 → 1107
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1277 → 1539
    CNH; CNH domain
    pfam15796
    Location:535 → 613
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  6. XM_021468486.2 → XP_021324161.1  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    A0A8M6YU74, A0A8M9PPH6
    Conserved Domains (7) summary
    pfam08826
    Location:887 → 947
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:438 → 945
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1117 → 1251
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 419
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1057 → 1107
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1277 → 1539
    CNH; CNH domain
    pfam15796
    Location:535 → 613
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  7. XM_021468485.2 → XP_021324160.1  serine/threonine-protein kinase MRCK alpha isoform X6

    UniProtKB/TrEMBL
    A0A8M9P2P6, A0A8M9PSV8
    Conserved Domains (7) summary
    pfam08826
    Location:887 → 947
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:438 → 945
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1104 → 1238
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 419
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1044 → 1094
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1264 → 1526
    CNH; CNH domain
    pfam15796
    Location:535 → 613
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  8. XM_068215518.1 → XP_068071619.1  serine/threonine-protein kinase MRCK alpha isoform X3

    UniProtKB/TrEMBL
    A0A8M2B7P3

  9. XM_068215521.1 → XP_068071622.1  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/TrEMBL
    A0A8M6YU74

  10. XM_005160751.5 → XP_005160808.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    A0A8M2B7M9, A0A8M6YU74
    Conserved Domains (8) summary
    pfam08826
    Location:880 → 940
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:506 → 781
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:1110 → 1244
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1050 → 1100
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1270 → 1532
    CNH; CNH domain
    pfam15796
    Location:528 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
Nucleotide Protein Strain
Heading Accession and Version

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