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ahsa1a AHA1, activator of heat shock protein ATPase homolog 1a [ Danio rerio (zebrafish) ]

Gene ID: 565968, updated on 9-Dec-2024

Summary

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Official Symbol
ahsa1aprovided by ZNC
Official Full Name
AHA1, activator of heat shock protein ATPase homolog 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1869
See related
Ensembl:ENSDARG00000028664 AllianceGenome:ZFIN:ZDB-GENE-030131-1869
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ahsa1; zgc:56075; wu:fb83b05; zgc:136821
Summary
Predicted to enable ATPase activator activity. Acts upstream of or within embryonic neurocranium morphogenesis. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; eye; gonad; heart; and muscle. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ahsa1a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (26967117..26974181)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (27067997..27075091)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-177p2.6 Neighboring gene cell division cycle associated 4 Neighboring gene SEL1L adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene si:dkey-177p2.18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR). Sheehan-Rooney K, et al. Dis Model Mech, 2013 Sep. PMID 23720234, Free PMC Article
  2. Gene expression and functional analysis of Aha1a and Aha1b in stress response in zebrafish. Xiao H, et al. Comp Biochem Physiol B Biochem Mol Biol, 2022 Oct-Dec. PMID 35830921, Free PMC Article
  3. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
  4. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
  5. Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. White RJ, et al. Elife, 2022 Feb 17. PMID 35175196, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene expression and functional analysis of Aha1a and Aha1b in stress response in zebrafish.
    Title: Gene expression and functional analysis of Aha1a and Aha1b in stress response in zebrafish.
  2. The chaperone proteins Ahsa1 and Hsp90 promote severe craniofacial phenotypes in zebrafish model of HDR syndrome.
    Title: Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC136821

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic neurocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 1a
Names
AHA1, activator of heat shock 90kDa protein ATPase homolog 1
AHA1, activator of heat shock protein ATPase homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045091.1 → NP_001038556.1  activator of 90 kDa heat shock protein ATPase homolog 1a

    Status: PROVISIONAL

    Source sequence(s)
    BX248515
    UniProtKB/TrEMBL
    A0A8M1NA94, Q5RIK5
    Related
    ENSDARP00000115845.1, ENSDART00000132434.3
    Conserved Domains (3) summary
    cd08892
    Location:186 → 311
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:7 → 136
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    COG5580
    Location:6 → 315
    COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    26967117..26974181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160576.5 → XP_005160633.1  activator of 90 kDa heat shock protein ATPase homolog 1a isoform X1

    See identical proteins and their annotated locations for XP_005160633.1

    UniProtKB/TrEMBL
    A0A8M2B7G0, Q29RB9
    Related
    ENSDARP00000032736.6, ENSDART00000029781.8
    Conserved Domains (3) summary
    cd08892
    Location:208 → 333
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29 → 158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    COG5580
    Location:19 → 337
    COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version

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