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pld2 phospholipase D2 [ Danio rerio (zebrafish) ]

Gene ID: 565743, updated on 4-Jan-2025

Summary

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Official Symbol
pld2provided by ZNC
Official Full Name
phospholipase D2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060216-4
See related
Ensembl:ENSDARG00000034262 AllianceGenome:ZFIN:ZDB-GENE-060216-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding activity; and phospholipase D activity. Predicted to act upstream of or within intracellular signal transduction; lipid catabolic process; and phosphatidic acid biosynthetic process. Is expressed in yolk syncytial layer. Orthologous to human PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pld2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38387285..38438944, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37790106..37838803, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 2 Neighboring gene misshapen-like kinase 1 Neighboring gene uncharacterized LOC137490148 Neighboring gene cholinergic receptor, nicotinic, epsilon Neighboring gene glycolipid transfer protein domain containing 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Liu HY, et al. Biochim Biophys Acta, 2010 Dec. PMID 20816853
  2. C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1. Yeh TH, et al. Exp Neurol, 2018 Jun. PMID 29522758
  3. n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Zhao Y, et al. Appl Microbiol Biotechnol, 2020 Mar. PMID 31950220
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase D2
XP_005165435.1
XP_009299966.1
XP_021327317.1
XP_021327319.1
XP_068077564.1
XP_694649.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    38387285..38438944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_689557.9 → XP_694649.4  phospholipase D2 isoform X1

    See identical proteins and their annotated locations for XP_694649.4

    UniProtKB/TrEMBL
    A0A8M2BCW6
    Related
    ENSDARP00000039697.7, ENSDART00000039698.7
    Conserved Domains (5) summary
    cd07297
    Location:56 → 182
    PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
    cd09843
    Location:323 → 467
    PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
    cd09845
    Location:628 → 809
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:81 → 939
    PLN02866; phospholipase D
    cd01254
    Location:171 → 297
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  2. XM_009301691.4 → XP_009299966.1  phospholipase D2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3ASP7
    Conserved Domains (5) summary
    cd07297
    Location:56 → 182
    PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
    cd09845
    Location:616 → 797
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:81 → 927
    PLN02866; phospholipase D
    cd01254
    Location:171 → 297
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl15239
    Location:323 → 455
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  3. XM_005165378.5 → XP_005165435.1  phospholipase D2 isoform X1

    See identical proteins and their annotated locations for XP_005165435.1

    UniProtKB/TrEMBL
    A0A8M2BCW6
    Related
    ENSDARP00000122561.1, ENSDART00000131912.3
    Conserved Domains (5) summary
    cd07297
    Location:56 → 182
    PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
    cd09843
    Location:323 → 467
    PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
    cd09845
    Location:628 → 809
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:81 → 939
    PLN02866; phospholipase D
    cd01254
    Location:171 → 297
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  4. XM_068221463.1 → XP_068077564.1  phospholipase D2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCW6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    122428..171085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471644.2 → XP_021327319.1  phospholipase D2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PR22
    Conserved Domains (1) summary
    cl26365
    Location:81 → 927
    PLN03008; Phospholipase D delta

  2. XM_021471642.2 → XP_021327317.1  phospholipase D2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P8Y7
    Conserved Domains (1) summary
    cl26365
    Location:81 → 939
    PLN03008; Phospholipase D delta
Nucleotide Protein Strain
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