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edc4 enhancer of mRNA decapping 4 [ Danio rerio (zebrafish) ]

Gene ID: 565659, updated on 9-Dec-2024

Summary

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Official Symbol
edc4provided by ZNC
Official Full Name
enhancer of mRNA decapping 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5032
See related
Ensembl:ENSDARG00000062266 AllianceGenome:ZFIN:ZDB-GENE-030131-5032
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fe26b05; wu:fe26b05; si:ch211-237c7.1
Summary
Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in cytoplasm and nucleus. Predicted to be active in P-body. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See edc4 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (21860517..21912228, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (21871451..21923162, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene protein serine kinase H1 Neighboring gene neuritin 1-like a Neighboring gene nuclear transport factor 2 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene RAN binding protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within deadenylation-independent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enhancer of mRNA-decapping protein 4
Names
autoantigen RCD8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045085.1 → NP_001038550.1  enhancer of mRNA-decapping protein 4

    See identical proteins and their annotated locations for NP_001038550.1

    Status: PROVISIONAL

    Source sequence(s)
    BX927240
    UniProtKB/Swiss-Prot
    Q1LUT1
    Related
    ENSDARP00000130250.1, ENSDART00000169220.2
    Conserved Domains (3) summary
    pfam16529
    Location:112 → 437
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:177 → 216
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:169 → 400
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    21860517..21912228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293574.3 → XP_009291849.1  enhancer of mRNA-decapping protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AJJ8
    Related
    ENSDARP00000148991.1, ENSDART00000191764.1
    Conserved Domains (3) summary
    pfam16529
    Location:112 → 437
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:177 → 216
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:169 → 400
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_021467677.2 → XP_021323352.1  enhancer of mRNA-decapping protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M9P146
    Related
    ENSDARP00000084220.5, ENSDART00000089787.6
    Conserved Domains (3) summary
    sd00039
    Location:177 → 216
    7WD40; WD40 repeat [structural motif]
    pfam16529
    Location:112 → 448
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    cl25548
    Location:829 → 1012
    DUF4670; Domain of unknown function (DUF4670)

  3. XM_021467676.2 → XP_021323351.1  enhancer of mRNA-decapping protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PM70
    Conserved Domains (3) summary
    sd00039
    Location:177 → 216
    7WD40; WD40 repeat [structural motif]
    pfam16529
    Location:112 → 448
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    cl25548
    Location:869 → 1052
    DUF4670; Domain of unknown function (DUF4670)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395341.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    228402..279126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1LUT1.1 GenPept UniProtKB/Swiss-Prot:Q1LUT1

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