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MMP26 matrix metallopeptidase 26 [ Homo sapiens (human) ]

Gene ID: 56547, updated on 27-Nov-2024

Summary

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Official Symbol
MMP26provided by HGNC
Official Full Name
matrix metallopeptidase 26provided by HGNC
Primary source
HGNC:HGNC:14249
See related
Ensembl:ENSG00000167346 MIM:605470; AllianceGenome:HGNC:14249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]
Expression
Restricted expression toward endometrium (RPKM 7.9) See more
Orthologs
all
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Genomic context

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See MMP26 in Genome Data Viewer
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4704784..4992429)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4770289..5049368)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4726014..5013659)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376528 Neighboring gene olfactory receptor family 51 subfamily E member 2 Neighboring gene olfactory receptor family 51 subfamily C member 1 Neighboring gene olfactory receptor family 51 subfamily F member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily C member 4 pseudogene Neighboring gene keratin 8 pseudogene 49 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene olfactory receptor family 51 subfamily F member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 4 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 1 Neighboring gene olfactory receptor family 51 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Y member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily R member 1 Neighboring gene olfactory receptor family 51 subfamily F member 2 Neighboring gene olfactory receptor family 51 subfamily A member 8 pseudogene Neighboring gene olfactory receptor family 51 subfamily S member 1 Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 51 subfamily H member 2 pseudogene Neighboring gene olfactory receptor family 51 subfamily T member 1 Neighboring gene olfactory receptor family 51 subfamily A member 6 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 7 Neighboring gene olfactory receptor family 51 subfamily G member 2 Neighboring gene olfactory receptor family 51 subfamily G member 1 Neighboring gene olfactory receptor family 51 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 4 Neighboring gene olfactory receptor family 51 subfamily A member 2 Neighboring gene olfactory receptor family 51 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily L member 1 Neighboring gene olfactory receptor family 51 subfamily P member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. Park HI, et al. J Biol Chem, 2000 Jul 7. PMID 10801841
  2. Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer. Li L, et al. Ai Zheng, 2009 Jan. PMID 19448419
  3. Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells. Zhao YG, et al. Ai Zheng, 2009 Nov. PMID 19895737
  4. Calcium regulates tertiary structure and enzymatic activity of human endometase/matrilysin-2 and its role in promoting human breast cancer cell invasion. Lee S, et al. Biochem J, 2007 Apr 1. PMID 17176253, Free PMC Article
  5. Expression of Matrix Metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo. Deng Y, et al. Oncol Rep, 2010 Jan. PMID 19956866

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker.
    Title: MMP26: A potential biomarker for prostate cancer.
  2. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro.
    Title: MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.
  3. MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma.
    Title: Circulating Hepatocellular Carcinoma Cells are Characterized by CXCR4 and MMP26.
  4. We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer
    Title: Activation of FGF receptor signaling promotes invasion of non-small-cell lung cancer.
  5. Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness.
    Title: Regulation of chondrosarcoma invasion by MMP26.
  6. The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15.
    Title: Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26.
  7. matrilysin-2 was an independent prognostic marker for patients with colorectal cancer
    Title: Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients.
  8. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation.
    Title: Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro.
  9. The MMP-26 promoter region contains a putative ER response element.
    Title: Estrogen and estrogen receptor induce matrix metalloproteinase-26 expression in endometrial carcinoma cells.
  10. expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion.
    Title: GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126590, MGC126592

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-26
Names
MMP-26
endometase
matrilysin 2
NP_001371537.1
NP_068573.2
XP_011518521.1
XP_054225330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384608.1 → NP_001371537.1  matrix metalloproteinase-26 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018375, AC090719, AC103710
    Consensus CDS
    CCDS91424.1
    UniProtKB/TrEMBL
    A0A8J8YUH5
    Related
    ENSP00000300762.2, ENST00000300762.2
    Conserved Domains (1) summary
    pfam00413
    Location:28 → 183
    Peptidase_M10; Matrixin

  2. NM_021801.5 → NP_068573.2  matrix metalloproteinase-26 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_068573.2

    Status: REVIEWED

    Source sequence(s)
    AC018375, AC090719, AC103710
    Consensus CDS
    CCDS7752.1
    UniProtKB/Swiss-Prot
    Q3MJ78, Q9GZS2, Q9NR87, Q9NRE1
    Related
    ENSP00000369753.1, ENST00000380390.6
    Conserved Domains (1) summary
    pfam00413
    Location:98 → 253
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    4704784..4992429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520219.3 → XP_011518521.1  matrix metalloproteinase-26 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YUH5
    Conserved Domains (1) summary
    pfam00413
    Location:28 → 183
    Peptidase_M10; Matrixin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    4770289..5049368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369355.1 → XP_054225330.1  matrix metalloproteinase-26 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YUH5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRE1.2 GenPept UniProtKB/Swiss-Prot:Q9NRE1

Gene LinkOut

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