comtb catechol-O-methyltransferase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: comtbprovided by ZNC
Official Full Name: catechol-O-methyltransferase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-164
See related: Ensembl:ENSDARG00000025679 AllianceGenome:ZFIN:ZDB-GENE-040724-164
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zK13A21.15; zgc:162236; si:dkey-13a21.15
Summary: Predicted to enable catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to act upstream of or within catecholamine metabolic process and methylation. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (25619932..25631442)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (25382244..25394383)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catechol O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catechol O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in catecholamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catechol O-methyltransferase B

Names: catechol O-methyltransferase

NP_001077312.1

EC 2.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083843.1 → NP_001077312.1 catechol O-methyltransferase B precursor

Status: PROVISIONAL

Source sequence(s)

BC134931

UniProtKB/Swiss-Prot

A4IG53, Q7SZX0

Related

ENSDARP00000038939.5, ENSDART00000033702.6

Conserved Domains (1) summary

COG4122
Location:67 → 261

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]