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hcfc1b host cell factor C1b [ Danio rerio (zebrafish) ]

Gene ID: 565206, updated on 9-Dec-2024

Summary

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Official Symbol
hcfc1bprovided by ZNC
Official Full Name
host cell factor C1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2411
See related
Ensembl:ENSDARG00000012519 AllianceGenome:ZFIN:ZDB-GENE-030131-2411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc07b09; fe17f08; wu:fc07b09; wu:fe17f08
Summary
Predicted to enable transcription coactivator activity. Acts upstream of or within chondrocyte differentiation and embryonic viscerocranium morphogenesis. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See hcfc1b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7506827..7567815, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (7488096..7549084, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene GATA binding protein 1b Neighboring gene cyclin dependent kinase 20 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene methyl CpG binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes. Castro VL, et al. Gene, 2023 May 15. PMID 36804358, Free PMC Article
  2. The first mecp2-null zebrafish model shows altered motor behaviors. Pietri T, et al. Front Neural Circuits, 2013. PMID 23874272, Free PMC Article
  3. Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression. Quintana AM, et al. Dev Biol, 2014 Dec 1. PMID 25281006, Free PMC Article
  4. Identification of the zebrafish maternal and paternal transcriptomes. Harvey SA, et al. Development, 2013 Jul. PMID 23720042, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC expression
    Title: Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
host cell factor 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128537.1 → NP_001122009.1  host cell factor 1b

    Status: PROVISIONAL

    Source sequence(s)
    BX571687
    UniProtKB/TrEMBL
    A0A8M9PQY4, A0A8M9Q3I3, A8WIP5
    Related
    ENSDARP00000121690.1, ENSDART00000132536.2
    Conserved Domains (4) summary
    sd00038
    Location:194 → 247
    Kelch; KELCH repeat [structural motif]
    cl25496
    Location:1138 → 1484
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26061
    Location:9 → 327
    PLN02193; nitrile-specifier protein
    cl26464
    Location:397 → 609
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    7506827..7567815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166699.5 → XP_005166756.1  host cell factor 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE35, A0A8M9Q3I3
    Conserved Domains (5) summary
    PLN02153
    Location:9 → 327
    PLN02153; epithiospecifier protein
    cd00063
    Location:1847 → 1951
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:194 → 247
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:26 → 63
    Kelch_1; Kelch motif
    pfam13415
    Location:209 → 257
    Kelch_3; Galactose oxidase, central domain

  2. XM_021478282.2 → XP_021333957.1  host cell factor 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQY4, A0A8M9Q3I3, A8WIP5
    Conserved Domains (4) summary
    sd00038
    Location:194 → 247
    Kelch; KELCH repeat [structural motif]
    cl25496
    Location:1138 → 1484
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26061
    Location:9 → 327
    PLN02193; nitrile-specifier protein
    cl26464
    Location:397 → 609
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version

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