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pim3 Pim-3 proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

Gene ID: 565041, updated on 4-Jan-2025

Summary

Official Symbol
pim3provided by ZNC
Official Full Name
Pim-3 proto-oncogene, serine/threonine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-111
See related
Ensembl:ENSDARG00000055129 AllianceGenome:ZFIN:ZDB-GENE-050809-111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:113028
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process and regulation of mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See pim3 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (29662352..29666902)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29219345..29223895)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor E-like Neighboring gene kelch repeat and BTB domain containing 13b Neighboring gene bromodomain containing 1b Neighboring gene TAFA chemokine like family member 5b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC113028

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase pim-3
Names
pim-3 oncogene
NP_001030150.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034978.2NP_001030150.2  serine/threonine-protein kinase pim-3

    Status: VALIDATED

    Source sequence(s)
    CU570887, EH435775, EH461773, EH552235, EH573361, EH579010, EH596371
    UniProtKB/TrEMBL
    A0A8M1N833, E7FB10
    Related
    ENSDARP00000071912.4, ENSDART00000077445.7
    Conserved Domains (2) summary
    cd14102
    Location:40292
    STKc_PIM3; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3
    pfam00069
    Location:41292
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    29662352..29666902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)