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Ankrd49 ankyrin repeat domain 49 [ Mus musculus (house mouse) ]

Gene ID: 56503, updated on 27-Nov-2024

Summary

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Official Symbol
Ankrd49provided by MGI
Official Full Name
ankyrin repeat domain 49provided by MGI
Primary source
MGI:MGI:1930842
See related
Ensembl:ENSMUSG00000031931 AllianceGenome:MGI:1930842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbif
Summary
Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ANKRD49 (ankyrin repeat domain 49). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 10.2), liver E14 (RPKM 7.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd49 in Genome Data Viewer
Location:
9 A2; 9 4.33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14690916..14695869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14779620..14784573, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23359 Neighboring gene RIKEN cDNA 1700012B09 gene Neighboring gene fucosyltransferase 4 Neighboring gene STARR-seq mESC enhancer starr_23360 Neighboring gene MRE11A homolog A, double strand break repair nuclease Neighboring gene macrophage migration inhibitory factor, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway. Wang HL, et al. PLoS One, 2015. PMID 26043108, Free PMC Article
  2. ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway. Liu YH, et al. J Cell Mol Med, 2022 Aug. PMID 35775112, Free PMC Article
  3. Cloning and characterization of a potential transcriptional activator of human gamma-globin genes. Yang Y, et al. Blood Cells Mol Dis, 2001 Jan-Feb. PMID 11162141
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway.
    Title: ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway.
  2. ANKRD49 plays an important role in spermatogenesis via promotion of autophagy-dependent survival.
    Title: The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25252

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 49
Names
fetal globin inducing factor
fetal globin-increasing factor
globin inducing factor, fetal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348260.1 → NP_001335189.1  ankyrin repeat domain-containing protein 49

    Status: VALIDATED

    Source sequence(s)
    AK132850, AK137504, BY547905, CD548941, CF105634, CT030247
    Consensus CDS
    CCDS22826.1
    UniProtKB/Swiss-Prot
    Q8VE42, Q9Z2S1
    Related
    ENSMUSP00000149874.2, ENSMUST00000216037.2
    Conserved Domains (2) summary
    sd00045
    Location:77 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:77 → 169
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_019683.4 → NP_062657.2  ankyrin repeat domain-containing protein 49

    See identical proteins and their annotated locations for NP_062657.2

    Status: VALIDATED

    Source sequence(s)
    AK132850, AK137504, BY204553, BY547905, CD548941
    Consensus CDS
    CCDS22826.1
    UniProtKB/Swiss-Prot
    Q8VE42, Q9Z2S1
    Related
    ENSMUSP00000151079.2, ENSMUST00000216372.2
    Conserved Domains (2) summary
    sd00045
    Location:77 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:77 → 169
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14690916..14695869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510503.3 → XP_006510566.1  ankyrin repeat domain-containing protein 49 isoform X1

    See identical proteins and their annotated locations for XP_006510566.1

    UniProtKB/Swiss-Prot
    Q8VE42, Q9Z2S1
    Conserved Domains (2) summary
    sd00045
    Location:77 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:77 → 169
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE42.1 GenPept UniProtKB/Swiss-Prot:Q8VE42

Gene LinkOut

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