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wfikkn2a info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a [ Danio rerio (zebrafish) ]

Gene ID: 564992, updated on 9-Dec-2024

Summary

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Official Symbol
wfikkn2aprovided by ZNC
Official Full Name
info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120914-1
See related
Ensembl:ENSDARG00000013460 AllianceGenome:ZFIN:ZDB-GENE-120914-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Gasp1a; wfikkn2
Summary
Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in transforming growth factor beta receptor signaling pathway. Predicted to be active in extracellular space. Is expressed in hindbrain; pectoral fin bud; and post-vent region. Orthologous to human WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See wfikkn2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (18097625..18105178)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (17947587..17955124)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene ankyrin repeat domain 40 Neighboring gene uncharacterized LOC137490521 Neighboring gene uncharacterized LOC108182810 Neighboring gene transducer of ERBB2, 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. GASP/WFIKKN proteins: evolutionary aspects of their functions. Monestier O, et al. PLoS One, 2012. PMID 22937083, Free PMC Article
  2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Names
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
growth and differentiation associated serum protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    18097625..18105178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_688302.9 → XP_693394.5  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    Related
    ENSDARP00000025648.7, ENSDART00000021634.8
    Conserved Domains (7) summary
    smart00131
    Location:325 → 375
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00104
    Location:137 → 173
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:451 → 559
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam07679
    Location:209 → 303
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:382 → 433
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:43 → 89
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cl11960
    Location:223 → 303
    Ig; Immunoglobulin domain
Nucleotide Protein
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