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spag1a sperm associated antigen 1a [ Danio rerio (zebrafish) ]

Gene ID: 564953, updated on 4-Jan-2025

Summary

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Official Symbol
spag1aprovided by ZNC
Official Full Name
sperm associated antigen 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9443
See related
Ensembl:ENSDARG00000004017 AllianceGenome:ZFIN:ZDB-GENE-030131-9443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
spag1; cb1089; wu:fj78g10
Summary
Involved in axonemal dynein complex assembly. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including EVL; nervous system; pectoral fin musculature; periderm; and ventral mesenchyme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 28. Orthologous to human SPAG1 (sperm associated antigen 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See spag1a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (11985572..12018446)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (12066044..12098918)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene RNA polymerase II, I and III subunit K Neighboring gene uncharacterized LOC137488482 Neighboring gene ring finger protein 19A, RBR E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms. Knowles MR, et al. Am J Hum Genet, 2013 Oct 3. PMID 24055112, Free PMC Article
  2. Concentration-dependent effects of 17β-estradiol and bisphenol A on lipid deposition, inflammation and antioxidant response in male zebrafish (Danio rerio). Sun SX, et al. Chemosphere, 2019 Dec. PMID 31352104
  3. A spinal organ of proprioception for integrated motor action feedback. Picton LD, et al. Neuron, 2021 Apr 7. PMID 33577748
  4. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC162178

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dynein axonemal particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm-associated antigen 1A
Names
sperm associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089406.2 → NP_001082875.2  sperm-associated antigen 1A

    Status: VALIDATED

    Source sequence(s)
    EH503424, FP236813
    UniProtKB/Swiss-Prot
    A4QNV4, F1RBN2
    UniProtKB/TrEMBL
    A0A0H2UKG1, A0A8M1ND21
    Related
    ENSDARP00000104892.3, ENSDART00000130537.3
    Conserved Domains (3) summary
    sd00006
    Location:263 → 289
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:297 → 328
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:263 → 326
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    11985572..12018446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1RBN2.1 GenPept UniProtKB/Swiss-Prot:F1RBN2

Gene LinkOut

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