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abcg4a ATP-binding cassette, sub-family G (WHITE), member 4a [ Danio rerio (zebrafish) ]

Gene ID: 564842, updated on 9-Dec-2024

Summary

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Official Symbol
abcg4aprovided by ZNC
Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-39
See related
Ensembl:ENSDARG00000061047 AllianceGenome:ZFIN:ZDB-GENE-050517-39
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
abcg4; si:ch211-117m20.3
Summary
Predicted to enable ABC-type sterol transporter activity. Predicted to be involved in cholesterol efflux; cholesterol homeostasis; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See abcg4a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (30624173..30677286)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (30023944..30074030)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transcobalamin beta b Neighboring gene transcobalamin beta a Neighboring gene NHERF family PDZ scaffold protein 4b Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel ABC transporter: the first insight into zebrafish (Danio rerio) ABCH1. Popovic M, et al. Mar Environ Res, 2010. PMID 19926124
  2. Characterization of a BAC library from channel catfish Ictalurus punctatus: indications of high levels of chromosomal reshuffling among teleost genomes. Wang S, et al. Mar Biotechnol (NY), 2007 Nov-Dec. PMID 17671813
  3. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
  4. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
  5. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family G member 4
Names
ATP-binding cassette, sub-family G (WHITE), member 4
abcg1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    30624173..30677286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682593.8 → XP_687685.2  ATP-binding cassette sub-family G member 4

    UniProtKB/TrEMBL
    A0A8N7T5M8, A2BFT1
    Related
    ENSDARP00000116517.1, ENSDART00000141444.2
    Conserved Domains (3) summary
    cd03213
    Location:53 → 277
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:38 → 641
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:372 → 574
    ABC2_membrane; ABC-2 type transporter
Nucleotide Protein
Heading Accession and Version

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