gstr glutathione S-transferase rho [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gstrprovided by ZNC
Official Full Name: glutathione S-transferase rhoprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090507-1
See related: Ensembl:ENSDARG00000042620 AllianceGenome:ZFIN:ZDB-GENE-090507-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gstr1; zgc:162356
Summary: Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (770384..775539)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (770575..775730)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results imply the role of Gstr1 in metabolism of xenobiotics and protection of fish against deleterious environmental contaminants.
Title: Molecular characterization of zebrafish Gstr1, the only member of teleost-specific glutathione S- transferase class.

Submit: New GeneRIF Correction

General gene information

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Markers

AI496881 (e-PCR)
- UniSTS:206390

fb63h10 (e-PCR)
- UniSTS:189044

AI477467 (e-PCR)
- UniSTS:206462

fb65e01 (e-PCR)
- UniSTS:189067

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutathione S-transferase rho

Names: Rho-class glutathione S-transferase

NP_001038525.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045060.2 → NP_001038525.1 glutathione S-transferase rho

See identical proteins and their annotated locations for NP_001038525.1

Status: PROVISIONAL

Source sequence(s)

BC139572

UniProtKB/TrEMBL

A2V6B0, Q1L907

Related

ENSDARP00000062517.6, ENSDART00000062518.7

Conserved Domains (3) summary

cd00299
Location:99 → 199

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

COG0625
Location:5 → 207

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd00570
Location:5 → 78

GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...