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septin12 septin 12 [ Danio rerio (zebrafish) ]

Gene ID: 564600, updated on 9-Dec-2024

Summary

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Official Symbol
septin12provided by ZNC
Official Full Name
septin 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-120215-68
See related
Ensembl:ENSDARG00000019191 AllianceGenome:ZFIN:ZDB-GENE-120215-68
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sept12; si:dkey-23a11.2
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See septin12 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (28502577..28627260)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (28371513..28496418)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 114 Neighboring gene RNA binding fox-1 homolog 1 Neighboring gene uncharacterized LOC137490603 Neighboring gene si:dkey-20j1.2 Neighboring gene uncharacterized LOC137490606 Neighboring gene F-box and leucine-rich repeat protein 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
  2. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
  3. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin-12; neuronal-specific septin-3; septin-9; uncharacterized protein septin12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    28502577..28627260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299472.4 → XP_009297747.1  uncharacterized protein septin12 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AY11, E7FGH0
    Related
    ENSDARP00000126089.1, ENSDART00000151081.3
    Conserved Domains (2) summary
    cd01850
    Location:523 → 797
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:505 → 800
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  2. XM_005163961.4 → XP_005164018.1  septin-9 isoform X3

    See identical proteins and their annotated locations for XP_005164018.1

    UniProtKB/TrEMBL
    A0A8M2BB45, I3ISV7
    Conserved Domains (2) summary
    cd01850
    Location:56 → 330
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:38 → 333
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. XM_005163960.5 → XP_005164017.1  septin-9 isoform X3

    See identical proteins and their annotated locations for XP_005164017.1

    UniProtKB/TrEMBL
    A0A8M2BB45, I3ISV7
    Related
    ENSDARP00000126002.1, ENSDART00000151189.3
    Conserved Domains (2) summary
    cd01850
    Location:56 → 330
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:38 → 333
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. XM_687930.6 → XP_693022.3  neuronal-specific septin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8N7T7N9
    Conserved Domains (2) summary
    cd01850
    Location:74 → 348
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:56 → 351
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
Nucleotide Protein Strain
Heading Accession and Version

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