batf basic leucine zipper transcription factor, ATF-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: batfprovided by ZNC
Official Full Name: basic leucine zipper transcription factor, ATF-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-291
See related: Ensembl:ENSDARG00000011818 AllianceGenome:ZFIN:ZDB-GENE-041014-291
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: B-ATF; si:ch211-153j24.4
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to protozoan; hemopoiesis; and regulation of gene expression. Predicted to act upstream of or within cell differentiation and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human BATF (basic leucine zipper ATF-like transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46572506..46648555)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46668830..46743455)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 17 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 2 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in isotype switching	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphoid progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: basic leucine zipper transcriptional factor ATF-like

Names: B-cell-activating transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045059.1 → NP_001038524.1 basic leucine zipper transcriptional factor ATF-like

See identical proteins and their annotated locations for NP_001038524.1

Status: PROVISIONAL

Source sequence(s)

AL929435

UniProtKB/TrEMBL

A0A8M1N9V8, Q5SP65

Related

ENSDARP00000139650.1, ENSDART00000161320.2

Conserved Domains (1) summary

cd14701
Location:1 → 57

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

46572506..46648555

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468479.2 → XP_021324154.2 basic leucine zipper transcriptional factor ATF-like isoform X2
XM_005160860.5 → XP_005160917.1 basic leucine zipper transcriptional factor ATF-like isoform X1

See identical proteins and their annotated locations for XP_005160917.1

UniProtKB/Swiss-Prot

F1QW76

Related

ENSDARP00000014497.4, ENSDART00000005548.6

Conserved Domains (1) summary

cd14701
Location:27 → 84

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain