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wwp2 WW domain containing E3 ubiquitin protein ligase 2 [ Danio rerio (zebrafish) ]

Gene ID: 564527, updated on 9-Dec-2024

Summary

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Official Symbol
wwp2provided by ZNC
Official Full Name
WW domain containing E3 ubiquitin protein ligase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-000607-82
See related
Ensembl:ENSDARG00000061345 AllianceGenome:ZFIN:ZDB-GENE-000607-82
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd1121; wu:fo87e10; zgc:154036
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Acts upstream of or within roof of mouth development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in brain; germ ring; head; pectoral fin bud; and tail bud. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See wwp2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (34749179..34804029)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (34243127..34299071)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 160 Neighboring gene fibroblast growth factor receptor substrate 2b Neighboring gene microRNA 140 Neighboring gene adenosine deaminase tRNA specific 1 Neighboring gene GABA(A) receptor-associated protein like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Zhang R, et al. Inflamm Res, 2013 Oct. PMID 23942573
  2. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. Nakamura Y, et al. J Musculoskelet Neuronal Interact, 2008 Oct-Dec. PMID 19147957, Free PMC Article
  3. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nakamura Y, et al. Nat Commun, 2011. PMID 21427722, Free PMC Article
  4. Itch is required for lateral line development in zebrafish. Angers A, et al. PLoS One, 2014. PMID 25369329, Free PMC Article
  5. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts. He X, et al. Zebrafish, 2011 Mar. PMID 21288128, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP2
NP_001092918.1
XP_005163228.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099448.1 → NP_001092918.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

    See identical proteins and their annotated locations for NP_001092918.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129043
    UniProtKB/TrEMBL
    A0A2R8RWE6, A0A8M6Z4C8, A2VCZ7, F6PEA4
    Related
    ENSDARP00000154551.1, ENSDART00000185712.1
    Conserved Domains (5) summary
    cd04021
    Location:17 → 145
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:297 → 326
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:535 → 863
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:512 → 864
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:402 → 430
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    34749179..34804029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163171.5 → XP_005163228.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAJ0, A0A8M6Z4C8, F6P346
    Related
    ENSDARP00000081798.4, ENSDART00000087364.6
    Conserved Domains (5) summary
    cd04021
    Location:17 → 145
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:298 → 327
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:536 → 864
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:513 → 865
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:403 → 431
    WW; WW domain
Nucleotide Protein
Heading Accession and Version

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