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tut1 terminal uridylyl transferase 1, U6 snRNA-specific [ Danio rerio (zebrafish) ]

Gene ID: 564388, updated on 9-Dec-2024

Summary

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Official Symbol
tut1provided by ZNC
Official Full Name
terminal uridylyl transferase 1, U6 snRNA-specificprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050706-68
See related
Ensembl:ENSDARG00000057321 AllianceGenome:ZFIN:ZDB-GENE-050706-68
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112254
Summary
Predicted to enable enzyme-substrate adaptor activity; mRNA 3'-UTR binding activity; and nucleotidyltransferase activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and snRNA processing. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in mitochondrion and nuclear speck. Is expressed in head; ovary; and testis. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See tut1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10337676..10351959, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10299833..10314116, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene MAGUK p55 scaffold protein 2b Neighboring gene peptide YYb Neighboring gene NDC80 kinetochore complex component Neighboring gene marker of proliferation Ki-67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Chang H, et al. Mol Cell, 2018 Apr 5. PMID 29625039
  2. Hen1 is required for oocyte development and piRNA stability in zebrafish. Kamminga LM, et al. EMBO J, 2010 Nov 3. PMID 20859253, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112254

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA uridylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
speckle targeted PIP5K1A-regulated poly(A) polymerase
Names
RNA-binding motif protein 21
RNA-binding protein 21
U6 snRNA-specific terminal uridylyltransferase 1
U6-TUTase
star-PAP
NP_001025359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030188.1 → NP_001025359.1  speckle targeted PIP5K1A-regulated poly(A) polymerase

    See identical proteins and their annotated locations for NP_001025359.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098614
    UniProtKB/Swiss-Prot
    Q4KMD7
    Related
    ENSDARP00000074395.4, ENSDART00000079945.5
    Conserved Domains (6) summary
    cd05402
    Location:179 → 327
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00451
    Location:11 → 38
    ZnF_U1; U1-like zinc finger
    COG0724
    Location:47 → 134
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12279
    Location:52 → 125
    RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins
    sd00020
    Location:16 → 38
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03828
    Location:421 → 495
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10337676..10351959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KMD7.1 GenPept UniProtKB/Swiss-Prot:Q4KMD7

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