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arhgap27 Rho GTPase activating protein 27 [ Danio rerio (zebrafish) ]

Gene ID: 564211, updated on 4-Jan-2025

Summary

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Official Symbol
arhgap27provided by ZNC
Official Full Name
Rho GTPase activating protein 27provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3922
See related
Ensembl:ENSDARG00000104255 AllianceGenome:ZFIN:ZDB-GENE-030131-3922
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc59a09; wu:fc59a09
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Is expressed in ectoderm. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See arhgap27 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4971852..5046139)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4936731..5009347)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene interferon phi 4 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene kinesin family member 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Optogenetic control of YAP cellular localisation and function. Toh PJY, et al. EMBO Rep, 2022 Sep 5. PMID 35876586, Free PMC Article
  2. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 15; rho GTPase-activating protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    4971852..5046139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156026.5 → XP_005156083.1  rho GTPase-activating protein 27 isoform X1

    See identical proteins and their annotated locations for XP_005156083.1

    UniProtKB/TrEMBL
    A0A8M2B2D3, A0A8M9PWQ0
    Conserved Domains (5) summary
    cd04403
    Location:808 → 992
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:614 → 725
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:613 → 726
    PH; PH domain
    pfam00397
    Location:382 → 410
    WW; WW domain
    cl17036
    Location:22 → 77
    SH3; Src Homology 3 domain superfamily

  2. XM_021480216.2 → XP_021335891.1  rho GTPase-activating protein 27 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PWQ0, A0A8M9QIZ3
    Conserved Domains (5) summary
    cd04403
    Location:784 → 968
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:590 → 701
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:382 → 410
    WW; WW domain
    cl17036
    Location:22 → 77
    SH3; Src Homology 3 domain superfamily
    cl28033
    Location:144 → 525
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. XM_005156029.5 → XP_005156086.1  rho GTPase-activating protein 27 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B2N4, A0A8M9PWQ0, E7FCI7
    Related
    ENSDARP00000132429.1, ENSDART00000161076.2
    Conserved Domains (5) summary
    cd04403
    Location:779 → 963
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:585 → 696
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:584 → 697
    PH; PH domain
    pfam00397
    Location:382 → 410
    WW; WW domain
    cl17036
    Location:22 → 77
    SH3; Src Homology 3 domain superfamily

  4. XM_005156027.5 → XP_005156084.1  rho GTPase-activating protein 27 isoform X1

    See identical proteins and their annotated locations for XP_005156084.1

    UniProtKB/TrEMBL
    A0A8M2B2D3, A0A8M9PWQ0
    Conserved Domains (5) summary
    cd04403
    Location:808 → 992
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:614 → 725
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:613 → 726
    PH; PH domain
    pfam00397
    Location:382 → 410
    WW; WW domain
    cl17036
    Location:22 → 77
    SH3; Src Homology 3 domain superfamily

  5. XM_009306431.4 → XP_009304706.1  rho GTPase-activating protein 15 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B778
    Conserved Domains (4) summary
    cd04403
    Location:589 → 773
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:395 → 506
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:394 → 507
    PH; PH domain
    pfam00397
    Location:163 → 191
    WW; WW domain

  6. XM_002663903.7 → XP_002663949.3  rho GTPase-activating protein 15 isoform X5

    UniProtKB/TrEMBL
    A0A8M1RHJ9
    Conserved Domains (4) summary
    cd04403
    Location:572 → 756
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:378 → 489
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:377 → 490
    PH; PH domain
    pfam00397
    Location:146 → 174
    WW; WW domain
Nucleotide Protein
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