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magi2a membrane associated guanylate kinase, WW and PDZ domain containing 2a [ Danio rerio (zebrafish) ]

Gene ID: 564112, updated on 4-Jan-2025

Summary

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Official Symbol
magi2aprovided by ZNC
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050810-4
See related
Ensembl:ENSDARG00000021590 AllianceGenome:ZFIN:ZDB-GENE-050810-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
magi2; fb82g11; wu:fb82g11; si:dkey-97c7.1; si:dkeyp-86a5.1
Summary
Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within pronephric glomerulus development. Predicted to be located in membrane. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See magi2a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22755465..23083187, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (23034490..23362212, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Neighboring gene nucleoporin 107 Neighboring gene uncharacterized LOC137491549 Neighboring gene solute carrier family 35 member E3 Neighboring gene MDM2 proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout. Jobst-Schwan T, et al. Kidney Int, 2019 May. PMID 31010479, Free PMC Article
  2. Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. Dong L, et al. J Am Soc Nephrol, 2015 Sep. PMID 25556170, Free PMC Article
  3. Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Fink IR, et al. Mol Immunol, 2015 Feb. PMID 25306962
  4. Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. He Z, et al. Biochem Biophys Res Commun, 2019 Sep 10. PMID 31349972, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-1 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables type II activin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pronephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a
Names
membrane associated guanylate kinase, WW and PDZ domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327853.1 → NP_001314782.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a

    Status: PROVISIONAL

    Source sequence(s)
    AL935183, AL935187, BX897665, CR392369
    UniProtKB/TrEMBL
    A0A8M1P8D6, A0A8M6Z5C9, F1Q897
    Related
    ENSDARP00000019515.9, ENSDART00000009768.9
    Conserved Domains (5) summary
    smart00228
    Location:431 → 511
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:307 → 337
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:1182 → 1262
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:352 → 381
    WW; WW domain
    cl17190
    Location:122 → 286
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    22755465..23083187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017355040.3 → XP_017210529.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X19

    UniProtKB/TrEMBL
    A0A8M6YX18, A0A8M6Z5C9

  2. XM_017355042.3 → XP_017210531.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X18

    UniProtKB/TrEMBL
    A0A8M6YY10, A0A8M6Z5C9

  3. XM_068219691.1 → XP_068075792.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X16

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  4. XM_068219683.1 → XP_068075784.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X9

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  5. XM_068219685.1 → XP_068075786.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X11

    UniProtKB/TrEMBL
    A0A8M6Z5Z3

  6. XM_068219684.1 → XP_068075785.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X10

    UniProtKB/TrEMBL
    A0A8M6YZJ4

  7. XM_068219680.1 → XP_068075781.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  8. XM_068219677.1 → XP_068075778.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  9. XM_068219679.1 → XP_068075780.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  10. XM_068219678.1 → XP_068075779.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X4

    UniProtKB/TrEMBL
    A0A8M9PHB4

  11. XM_068219682.1 → XP_068075783.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X8

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  12. XM_068219681.1 → XP_068075782.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X7

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  13. XM_068219676.1 → XP_068075777.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  14. XM_068219675.1 → XP_068075776.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5C9

  15. XM_017355045.3 → XP_017210534.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X17

    UniProtKB/TrEMBL
    A0A8M6YX22, A0A8M6Z5D1
    Related
    ENSDARP00000118891.1, ENSDART00000133644.3

  16. XM_068219690.1 → XP_068075791.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X15

    UniProtKB/TrEMBL
    A0A8M6Z5D1

  17. XM_068219687.1 → XP_068075788.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X13

    UniProtKB/TrEMBL
    A0A8M6Z5D1

  18. XM_068219686.1 → XP_068075787.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X12

    UniProtKB/TrEMBL
    A0A8M6Z5D1

  19. XM_068219688.1 → XP_068075789.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X14

    UniProtKB/TrEMBL
    A0A8M6YY15

  20. XM_068219689.1 → XP_068075790.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X14

    UniProtKB/TrEMBL
    A0A8M6YY15

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394554.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    5075..229652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395231.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    2859..258335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122611.1: Suppressed sequence

    Description
    NM_001122611.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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