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trmt5 tRNA methyltransferase 5 [ Danio rerio (zebrafish) ]

Gene ID: 564078, updated on 9-Dec-2024

Summary

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Official Symbol
trmt5provided by ZNC
Official Full Name
tRNA methyltransferase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5978
See related
Ensembl:ENSDARG00000069278 AllianceGenome:ZFIN:ZDB-GENE-030131-5978
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi28b08
Summary
Predicted to enable tRNA (guanine(37)-N1)-methyltransferase activity and tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See trmt5 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31681988..31687925, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31551510..31566334, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SIX homeobox 4a Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene solute carrier family 38 member 6 Neighboring gene protein kinase C, eta, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Gómez-Marín C, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034287, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (guanine(37)-N1)-methyltransferase
Names
TRM5 tRNA methyltransferase 5 homolog
tRNA (guanine-N(1)-)-methyltransferase
NP_001139055.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145583.1 → NP_001139055.1  tRNA (guanine(37)-N1)-methyltransferase

    See identical proteins and their annotated locations for NP_001139055.1

    Status: PROVISIONAL

    Source sequence(s)
    BX537123
    UniProtKB/Swiss-Prot
    B8A5G9
    UniProtKB/TrEMBL
    A0A8M3AZ45
    Related
    ENSDARP00000080424.4, ENSDART00000085989.5
    Conserved Domains (2) summary
    pfam02475
    Location:183 → 384
    Met_10; Met-10+ like-protein
    pfam12847
    Location:282 → 343
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    31681988..31687925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8A5G9.1 GenPept UniProtKB/Swiss-Prot:B8A5G9

Gene LinkOut

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