U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

usp38 ubiquitin specific peptidase 38 [ Danio rerio (zebrafish) ]

Gene ID: 563778, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
usp38provided by ZNC
Official Full Name
ubiquitin specific peptidase 38provided by ZNC
Primary source
ZFIN:ZDB-GENE-101007-2
See related
Ensembl:ENSDARG00000075798 AllianceGenome:ZFIN:ZDB-GENE-101007-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to act upstream of or within protein deubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in female organism. Orthologous to human USP38 (ubiquitin specific peptidase 38). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See usp38 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (35473385..35488739)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (34741324..34756712)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene B- and T-lymphocyte attenuator-like Neighboring gene uncharacterized LOC137495583 Neighboring gene GRB2-associated binding protein 1 Neighboring gene Fras1 related extracellular matrix 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. Tsai IC, et al. JCI Insight, 2019 Nov 14. PMID 31723061, Free PMC Article
  2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
  3. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
  4. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  5. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 38
XP_003197722.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    35473385..35488739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003197674.6 → XP_003197722.1  ubiquitin carboxyl-terminal hydrolase 38

    UniProtKB/TrEMBL
    A0A8M1RIE1, F1RBA1
    Related
    ENSDARP00000101307.3, ENSDART00000109678.5
    Conserved Domains (2) summary
    cd02664
    Location:446 → 918
    Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:445 → 917
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools