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gpr4 G protein-coupled receptor 4 [ Danio rerio (zebrafish) ]

Gene ID: 563762, updated on 4-Jan-2025

Summary

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Official Symbol
gpr4provided by ZNC
Official Full Name
G protein-coupled receptor 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-101202-1
See related
Ensembl:ENSDARG00000079479 AllianceGenome:ZFIN:ZDB-GENE-101202-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and response to acidic pH. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See gpr4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28817563..28860225, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28890238..28927322, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene RNA polymerase I subunit G Neighboring gene uncharacterized protein PF3D7_1120000-like Neighboring gene EMAP like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish. Mochimaru Y, et al. Biochem Biophys Res Commun, 2015 Feb 20. PMID 25576873
  2. Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4. Negishi J, et al. J Recept Signal Transduct Res, 2017 Aug. PMID 28270026
  3. Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Lou L, et al. Proc Natl Acad Sci U S A, 2022 Sep 27. PMID 36122226, Free PMC Article
  4. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    28817563..28860225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157675.5 → XP_005157732.1  G-protein coupled receptor 4

    See identical proteins and their annotated locations for XP_005157732.1

    UniProtKB/TrEMBL
    A0A8M2B4J4, E7FEL0
    Related
    ENSDARP00000129226.1, ENSDART00000156738.2
    Conserved Domains (2) summary
    pfam00001
    Location:43 → 294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33 → 176
    7tm_4; Olfactory receptor
Nucleotide Protein Strain
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