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usp21 ubiquitin specific peptidase 21 [ Danio rerio (zebrafish) ]

Gene ID: 563546, updated on 9-Dec-2024

Summary

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Official Symbol
usp21provided by ZNC
Official Full Name
ubiquitin specific peptidase 21provided by ZNC
Primary source
ZFIN:ZDB-GENE-100210-3
See related
Ensembl:ENSDARG00000094280 AllianceGenome:ZFIN:ZDB-GENE-100210-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See usp21 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20687340..20701863)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20760997..20775518)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 3, like Neighboring gene coiled-coil domain containing 30 Neighboring gene zinc finger protein 362b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 21

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    20687340..20701863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162129.5 → XP_005162186.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B8Z0
    Conserved Domains (2) summary
    cd02674
    Location:63 → 396
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:62 → 395
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_686911.9 → XP_692003.2  ubiquitin carboxyl-terminal hydrolase 21 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TF44, E9QFQ5
    Related
    ENSDARP00000122828.2, ENSDART00000143503.3
    Conserved Domains (2) summary
    cd02674
    Location:63 → 395
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:62 → 394
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
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