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plekho1a pleckstrin homology domain containing, family O member 1a [ Danio rerio (zebrafish) ]

Gene ID: 563283, updated on 4-Jan-2025

Summary

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Official Symbol
plekho1aprovided by ZNC
Official Full Name
pleckstrin homology domain containing, family O member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-433
See related
Ensembl:ENSDARG00000061191 AllianceGenome:ZFIN:ZDB-GENE-060503-433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ckip-1; plekho1; si:dkey-200h23.2
Summary
Predicted to be involved in regulation of myoblast fusion. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See plekho1a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (42367286..42391496, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (42797849..42822156, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-191i18.2 Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member E Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene zgc:153441

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in regulation of myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in muscle cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family O member 1-A
Names
CK2-interacting protein-1
PH domain-containing family O member 1
PH domain-containing family O member 1-A
casein kinase 2-interacting protein 1
pleckstrin homology domain-containing family O member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110463.1 → NP_001103933.1  pleckstrin homology domain-containing family O member 1-A

    See identical proteins and their annotated locations for NP_001103933.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134933
    UniProtKB/Swiss-Prot
    A4IG55, A5A8K2, A8E7N4
    Related
    ENSDARP00000103674.2, ENSDART00000110075.4
    Conserved Domains (2) summary
    cd13317
    Location:17 → 126
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
    pfam00169
    Location:25 → 130
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    42367286..42391496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159748.5 → XP_005159805.1  pleckstrin homology domain-containing family O member 1-A isoform X1

    UniProtKB/Swiss-Prot
    A4IG55, A5A8K2, A8E7N4
    UniProtKB/TrEMBL
    A0A8M2B6E0, Z4YHZ1
    Related
    ENSDARP00000081436.4, ENSDART00000087002.5
    Conserved Domains (2) summary
    cd13317
    Location:17 → 126
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
    pfam00169
    Location:25 → 130
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IG55.2 GenPept UniProtKB/Swiss-Prot:A4IG55

Gene LinkOut

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