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lonp1 lon peptidase 1, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 563257, updated on 4-Jan-2025

Summary

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Official Symbol
lonp1provided by ZNC
Official Full Name
lon peptidase 1, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4006
See related
Ensembl:ENSDARG00000102765 AllianceGenome:ZFIN:ZDB-GENE-030131-4006
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prss15; fc64d11; wu:fc64d11
Summary
Predicted to enable ATP-dependent peptidase activity and single-stranded DNA binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; mitochondrion organization; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to act upstream of or within protein catabolic process and proteolysis. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in caudal fin and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See lonp1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (3161164..3182763, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (3143901..3165567, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene lamin B2 Neighboring gene ribosomal protein L36 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3 Neighboring gene pumilio homolog 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response. Lin YF, et al. iScience, 2021 Oct 22. PMID 34622167, Free PMC Article
  2. Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease. Kim D, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800130, Free PMC Article
  3. Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. Wen W, et al. PLoS One, 2023. PMID 38032938, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxidation-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lon protease homolog, mitochondrial
Names
protease, serine, 15
XP_691712.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    3161164..3182763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686620.10 → XP_691712.4  lon protease homolog, mitochondrial

    UniProtKB/TrEMBL
    A0A0R4IH79, A0A8N7T7A0
    Related
    ENSDARP00000134801.1, ENSDART00000158009.2
    Conserved Domains (5) summary
    smart00464
    Location:131 → 228
    LON; Found in ATP-dependent protease La (LON)
    TIGR00763
    Location:132 → 962
    lon; endopeptidase La
    pfam00004
    Location:533 → 675
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21455
    Location:489 → 564
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl21678
    Location:751 → 957
    ChlI; Subunit ChlI of Mg-chelatase
Nucleotide Protein
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