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hectd3 HECT domain containing 3 [ Danio rerio (zebrafish) ]

Gene ID: 563189, updated on 4-Jan-2025

Summary

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Official Symbol
hectd3provided by ZNC
Official Full Name
HECT domain containing 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-031118-179
See related
Ensembl:ENSDARG00000038905 AllianceGenome:ZFIN:ZDB-GENE-031118-179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc38h02; zgc:153380
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Is expressed in hatching gland; notochord; and polster. Orthologous to human HECTD3 (HECT domain E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See hectd3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (26479676..26495044)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (26823856..26839410)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene small nucleolar RNA SNORD46 Neighboring gene small nucleolar RNA SNORD38 Neighboring gene ribosomal protein S8a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0076, MGC153380

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD3
NP_001070627.2
XP_009296823.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077159.2 → NP_001070627.2  E3 ubiquitin-protein ligase HECTD3

    Status: VALIDATED

    Source sequence(s)
    BX569796, DY573793, EE299689, EH515969, EL646535
    UniProtKB/TrEMBL
    A0A8M1NAZ3, F1QF19
    Related
    ENSDARP00000056794.5, ENSDART00000056795.7
    Conserved Domains (3) summary
    cd08666
    Location:231 → 366
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    smart00119
    Location:523 → 842
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:561 → 838
    HECT; HECT-domain (ubiquitin-transferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    26479676..26495044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298548.3 → XP_009296823.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B7Q8
    Conserved Domains (3) summary
    cd08666
    Location:231 → 365
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    smart00119
    Location:522 → 841
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:560 → 837
    HECT; HECT-domain (ubiquitin-transferase)
Nucleotide Protein Strain
Heading Accession and Version

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