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dapk3 death-associated protein kinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 562194, updated on 4-Jan-2025

Summary

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Official Symbol
dapk3provided by ZNC
Official Full Name
death-associated protein kinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3026
See related
Ensembl:ENSDARG00000074447 AllianceGenome:ZFIN:ZDB-GENE-030131-3026
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc25b08; si:dkey-57k2.5
Summary
Enables protein kinase activity. Predicted to be involved in intracellular signal transduction and positive regulation of apoptotic process. Predicted to act upstream of or within protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See dapk3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37467938..37478434, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37486326..37496059, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene polyhomeotic homolog 3 (Drosophila) Neighboring gene si:dkey-127k13.1 Neighboring gene signal peptide peptidase-like 2 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the zebrafish homolog of zipper interacting protein kinase. Carr BW, et al. Int J Mol Sci, 2014 Jun 30. PMID 24983477, Free PMC Article
  2. ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene. Shoval Y, et al. PLoS Genet, 2007 Oct. PMID 17953487, Free PMC Article
  3. Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Castets M, et al. Dev Cell, 2009 Apr. PMID 19386270
  4. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Blaser H, et al. Dev Cell, 2006 Nov. PMID 17084355
  5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
death-associated protein kinase 3
Names
zipk
XP_690685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37467938..37478434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685593.9 → XP_690685.1  death-associated protein kinase 3

    UniProtKB/TrEMBL
    A0A8N7UT33, E9QHI3
    Related
    ENSDARP00000120152.1, ENSDART00000146103.2
    Conserved Domains (2) summary
    smart00220
    Location:13 → 275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14105
    Location:7 → 275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RNA

  1. XR_011006884.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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