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fignl2 fidgetin like 2 [ Danio rerio (zebrafish) ]

Gene ID: 561837, updated on 4-Jan-2025

Summary

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Official Symbol
fignl2provided by ZNC
Official Full Name
fidgetin like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-189
See related
Ensembl:ENSDARG00000057062 AllianceGenome:ZFIN:ZDB-GENE-090313-189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc13c02; wu:fc13c02; si:dkey-157g16.6
Summary
Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in morphogenesis of a branching structure. Predicted to be located in cell cortex. Is expressed in several structures, including axis; hindbrain neural rod; nervous system; pectoral fin bud; and solid lens vesicle. Orthologous to human FIGNL2 (fidgetin like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See fignl2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27131654..27245023, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27205113..27226325, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene major intrinsic protein of lens fiber a Neighboring gene signal transducer and activator of transcription 6, interleukin-4 induced Neighboring gene uncharacterized LOC137489132 Neighboring gene uncharacterized LOC137489131 Neighboring gene sodium channel, voltage gated, type VIII, alpha subunit a Neighboring gene acrosin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development. Dong Z, et al. Front Cell Dev Biol, 2020. PMID 33585441, Free PMC Article
  2. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule severing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fidgetin-like protein 2
NP_001201837.1
XP_068072876.1
XP_068072877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001214908.1 → NP_001201837.1  fidgetin-like protein 2

    See identical proteins and their annotated locations for NP_001201837.1

    Status: VALIDATED

    Source sequence(s)
    CR354433
    UniProtKB/Swiss-Prot
    A0A8M1NZ11, E9QEA3
    Conserved Domains (2) summary
    smart00382
    Location:457 → 583
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:461 → 581
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    27131654..27245023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216775.1 → XP_068072876.1  fidgetin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0A8M1NZ11, E9QEA3

  2. XM_068216776.1 → XP_068072877.1  fidgetin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0A8M1NZ11, E9QEA3
    Related
    ENSDARP00000114769.1, ENSDART00000134418.3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395154.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    372699..393911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9QEA3.1 GenPept UniProtKB/Swiss-Prot:E9QEA3

Gene LinkOut

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