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slc5a5 solute carrier family 5 member 5 [ Danio rerio (zebrafish) ]

Gene ID: 561445, updated on 9-Dec-2024

Summary

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Official Symbol
slc5a5provided by ZNC
Official Full Name
solute carrier family 5 member 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-585
See related
Ensembl:ENSDARG00000005392 AllianceGenome:ZFIN:ZDB-GENE-060503-585
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-200a16.4
Summary
Enables sodium:iodide symporter activity. Acts upstream of or within iodide transport; monoatomic anion transmembrane transport; and sodium ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in brain; ovary; pharynx; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See slc5a5 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (13364950..13382354)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13327245..13344838)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1b Neighboring gene uncharacterized LOC110440006 Neighboring gene uncharacterized LOC101886813 Neighboring gene coiled-coil domain containing 124 Neighboring gene Janus kinase 3 (a protein tyrosine kinase, leukocyte) Neighboring gene novel protein similar to vertebrate pim oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis. Thienpont B, et al. Environ Sci Technol, 2011 Sep 1. PMID 21800831
  2. Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish. Holloway N, et al. Gen Comp Endocrinol, 2021 Jan 1. PMID 33002449
  3. Unraveling molecular targets of bisphenol A and S in the thyroid gland. Berto-Júnior C, et al. Environ Sci Pollut Res Int, 2018 Sep. PMID 30006815
  4. Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). Concilio SC, et al. PLoS One, 2020. PMID 32084174, Free PMC Article
  5. Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos. Fetter E, et al. Reprod Toxicol, 2015 Nov. PMID 25962731

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish.
    Title: Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sodium:iodide symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iodide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium/iodide cotransporter
Names
NIS
solute carrier family 5 (sodium iodide symporter), member 5
solute carrier family 5 (sodium/iodide cotransporter), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089391.1 → NP_001082860.1  sodium/iodide cotransporter

    See identical proteins and their annotated locations for NP_001082860.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134942
    UniProtKB/TrEMBL
    A0A0R4ICT1, A0A8M9QIL8, A4IG60
    Related
    ENSDARP00000130752.2, ENSDART00000159760.2
    Conserved Domains (1) summary
    cl00456
    Location:14 → 549
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    13364950..13382354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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