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gfral GDNF family receptor alpha like [ Danio rerio (zebrafish) ]

Gene ID: 561326, updated on 9-Dec-2024

Summary

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Official Symbol
gfralprovided by ZNC
Official Full Name
GDNF family receptor alpha likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110607-2
See related
Ensembl:ENSDARG00000089709 AllianceGenome:ZFIN:ZDB-GENE-110607-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in nervous system development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See gfral in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (1990538..2010278, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (1859898..1868583, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 5 Neighboring gene uncharacterized LOC110440169 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 Neighboring gene hypocretin (orexin) receptor 2 Neighboring gene family with sequence similarity 83 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs. Hätinen T, et al. Mol Cell Neurosci, 2007 Feb. PMID 17157029
  2. Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Pan W, et al. Sci Rep, 2022 Jun 16. PMID 35710785, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDNF family receptor alpha-like
Names
GRAL
zmp:0000000970

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    1990538..2010278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212986.1 → XP_068069087.1  GDNF family receptor alpha-like isoform X2

    Related
    ENSDARP00000107837.2, ENSDART00000124134.3

  2. XM_684733.10 → XP_689825.7  GDNF family receptor alpha-like isoform X1

    UniProtKB/TrEMBL
    A0A8N7UV70
    Conserved Domains (1) summary
    pfam02351
    Location:216 → 310
    GDNF; GDNF/GAS1 domain
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials