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myh7bb myosin, heavy chain 7B, cardiac muscle, beta b [ Danio rerio (zebrafish) ]

Gene ID: 560945, updated on 9-Dec-2024

Summary

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Official Symbol
myh7bbprovided by ZNC
Official Full Name
myosin, heavy chain 7B, cardiac muscle, beta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090311-5
See related
Ensembl:ENSDARG00000035322 AllianceGenome:ZFIN:ZDB-GENE-090311-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-209j10.4
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in system development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See myh7bb in Genome Data Viewer
Location:
chromosome: 23
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (18722730..18757170)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18795480..18830828)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489115 Neighboring gene zgc:103759 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein b Neighboring gene epithelial membrane protein 3b (MAM blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of the Expression of the Myosin Heavy Chain (MYH) Gene myh14 in Zebrafish Development. Hasan S, et al. Mar Biotechnol (NY), 2021 Oct. PMID 34490548
  2. Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene. Bhuiyan SS, et al. BMC Evol Biol, 2013 Jul 6. PMID 24059862, Free PMC Article
  3. Phenanthrene exposure produces cardiac defects during embryo development of zebrafish (Danio rerio) through activation of MMP-9. Zhang Y, et al. Chemosphere, 2013 Oct. PMID 23859427
  4. Obscurin Maintains Myofiber Identity in Extraocular Muscles. Kahsay A, et al. Invest Ophthalmol Vis Sci, 2024 Feb 1. PMID 38334702, Free PMC Article
  5. Evolution and Distribution of Teleost myomiRNAs: Functionally Diversified myomiRs in Teleosts. Siddique BS, et al. Mar Biotechnol (NY), 2016 Jun. PMID 27262998

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-7; uncharacterized protein LOC560945
Names
MYH14-2
myosin, heavy chain 7, cardiac muscle, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    18722730..18757170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296759.4 → XP_009295034.2  myosin-7 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AMS5, E9QF07
    Related
    ENSDARP00000114580.2, ENSDART00000137438.4

  2. XM_021469927.2 → XP_021325602.1  myosin-7 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P5E5
    Conserved Domains (2) summary
    cl22853
    Location:1 → 544
    Motor_domain; Myosin and Kinesin motor domain
    cl25732
    Location:624 → 1701
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version

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