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trak2 trafficking protein, kinesin binding 2 [ Danio rerio (zebrafish) ]

Gene ID: 560810, updated on 4-Jan-2025

Summary

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Official Symbol
trak2provided by ZNC
Official Full Name
trafficking protein, kinesin binding 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7496
See related
Ensembl:ENSDARG00000102471 AllianceGenome:ZFIN:ZDB-GENE-030131-7496
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj21g01; wu:fj21g01
Summary
Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including mitochondrion distribution; organelle transport along microtubule; and protein targeting. Predicted to be located in early endosome. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See trak2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (4184766..4228499, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (4024086..4067716, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb Neighboring gene tripartite motif containing 25, like Neighboring gene STE20 related adaptor beta Neighboring gene neurobeachin-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Trak proteins 1a and 2 localize to the mitochondria. Oonk KA, et al. MicroPubl Biol, 2020 Oct 16. PMID 33274332, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
trafficking kinesin-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    4184766..4228499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172086.5 → XP_005172143.1  trafficking kinesin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q3P3, A0A8M2BJC6
    Related
    ENSDARP00000147335.1, ENSDART00000179923.1
    Conserved Domains (4) summary
    pfam04849
    Location:35 → 329
    HAP1_N; HAP1 N-terminal conserved region
    pfam07106
    Location:250 → 332
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam12448
    Location:403 → 530
    Milton; Kinesin associated protein
    cl23720
    Location:182 → 311
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_684210.10 → XP_689302.5  trafficking kinesin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IDG7, A0A8N7T702
    Related
    ENSDARP00000133065.1, ENSDART00000162497.2
    Conserved Domains (4) summary
    pfam04849
    Location:35 → 348
    HAP1_N; HAP1 N-terminal conserved region
    pfam07106
    Location:269 → 351
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam12448
    Location:422 → 549
    Milton; Kinesin associated protein
    cl23720
    Location:201 → 330
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_021476982.2 → XP_021332657.1  trafficking kinesin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A2R8RYY2, A0A8M9PME8
    Related
    ENSDARP00000156274.1, ENSDART00000191433.1
    Conserved Domains (2) summary
    pfam04849
    Location:38 → 295
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:369 → 496
    Milton; Kinesin associated protein

  4. XM_005172089.5 → XP_005172146.1  trafficking kinesin-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BJY1
    Conserved Domains (4) summary
    TIGR04211
    Location:57 → 158
    SH3_and_anchor; SH3 domain protein
    pfam07106
    Location:202 → 276
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam12448
    Location:347 → 474
    Milton; Kinesin associated protein
    pfam15619
    Location:128 → 273
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
Nucleotide Protein Strain
Heading Accession and Version

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