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grk5 G protein-coupled receptor kinase 5 [ Danio rerio (zebrafish) ]

Gene ID: 560806, updated on 4-Jan-2025

Summary

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Official Symbol
grk5provided by ZNC
Official Full Name
G protein-coupled receptor kinase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-274
See related
Ensembl:ENSDARG00000032801 AllianceGenome:ZFIN:ZDB-GENE-091204-274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-171l20.1
Summary
Predicted to enable protein kinase activity. Acts upstream of or within heart development; positive regulation of Wnt signaling pathway; and regulation of heart contraction. Predicted to be active in cytoplasm. Is expressed in brain; cardiovascular system; and otic vesicle. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See grk5 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2715391..2755381)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2688377..2728207)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 9 Neighboring gene mesoderm induction early response 1, family member 3 a Neighboring gene ash2 like, histone lysine methyltransferase complex subunit Neighboring gene posterior neuron-specific homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. Philipp M, et al. J Biol Chem, 2014 Sep 19. PMID 25104355, Free PMC Article
  2. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. Chen M, et al. J Biol Chem, 2009 Dec 11. PMID 19801552, Free PMC Article
  3. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, et al. EMBO Rep, 2016 May. PMID 27113758, Free PMC Article
  4. Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. Burkhalter MD, et al. Cell Rep, 2013 Aug 29. PMID 23972986, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
    Title: Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.
  2. Grk5l influences development of the heart during its early formation.
    Title: Grk5l controls heart development by limiting mTOR signaling during symmetry breaking.
  3. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.
    Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G protein-coupled receptor kinase 5
NP_001166974.1
XP_021334860.1
XP_068079905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173503.1 → NP_001166974.1  G protein-coupled receptor kinase 5

    Status: VALIDATED

    Source sequence(s)
    BC155606, BQ419577, EH480419
    UniProtKB/TrEMBL
    A0A8M1NUN2, F1RAR9
    Related
    ENSDARP00000104968.2, ENSDART00000130793.4
    Conserved Domains (3) summary
    smart00220
    Location:180 → 443
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:35 → 173
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:180 → 464
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    2715391..2755381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223804.1 → XP_068079905.1  G protein-coupled receptor kinase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M1NUN2, F1RAR9

  2. XM_021479185.2 → XP_021334860.1  G protein-coupled receptor kinase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QKR0, A9JRC5
    Conserved Domains (2) summary
    cl02565
    Location:35 → 173
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:180 → 464
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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