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grk4 G protein-coupled receptor kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 560761, updated on 9-Dec-2024

Summary

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Official Symbol
grk4provided by ZNC
Official Full Name
G protein-coupled receptor kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-1198
See related
Ensembl:ENSDARG00000070448 AllianceGenome:ZFIN:ZDB-GENE-060929-1198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153020
Summary
Predicted to enable protein kinase activity. Acts upstream of or within cilium organization; pronephros development; and symbiont-mediated activation of host NF-kappaB cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; nervous system; notochord; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See grk4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (11902579..11973377, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11215779..11286572, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing E Neighboring gene uncharacterized LOC137495029 Neighboring gene sorting nexin 8b Neighboring gene tetraspanin 5b Neighboring gene solute carrier family 24 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. Gerhards J, et al. J Am Soc Nephrol, 2023 Apr 1. PMID 36810260, Free PMC Article
  2. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, et al. EMBO Rep, 2016 May. PMID 27113758, Free PMC Article
  3. Specific miRNA-G Protein-Coupled Receptor Networks Regulate Sox9a/Sox9b Activities to Promote Gonadal Rejuvenation in Zebrafish. Guo H, et al. Stem Cells, 2019 Sep. PMID 31116894
  4. Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. Valanne S, et al. J Immunol, 2010 Jun 1. PMID 20421637
  5. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within symbiont-mediated activation of host NF-kappaB cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
G protein-coupled receptor kinase 4
Names
GRK5
NP_001073455.1
NP_001349548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079986.2 → NP_001073455.1  G protein-coupled receptor kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001073455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX908747
    UniProtKB/TrEMBL
    A0A8M1NB48, Q08CJ6
    Related
    ENSDARP00000133992.1, ENSDART00000159981.2
    Conserved Domains (3) summary
    cd05631
    Location:185 → 469
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    cd08750
    Location:52 → 183
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    smart00220
    Location:186 → 448
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  2. NM_001362619.1 → NP_001349548.1  G protein-coupled receptor kinase 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX908747
    UniProtKB/TrEMBL
    A0A8M3BE02
    Conserved Domains (2) summary
    cd08750
    Location:52 → 183
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    cl21453
    Location:185 → 469
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    11902579..11973377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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