ces3 carboxylesterase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ces3provided by ZNC
Official Full Name: carboxylesterase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9563
See related: Ensembl:ENSDARG00000041595 AllianceGenome:ZFIN:ZDB-GENE-030131-9563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb66e04; wu:fi21c04; wu:fj87b08; si:dkey-38l12.3
Summary: Predicted to enable carboxylic ester hydrolase activity. Located in motile cilium. Is expressed in liver. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (17418270..17426311)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (17429204..17437245)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb58f03.x1 (e-PCR)
- UniSTS:190815

fb58f03.x1 (e-PCR)
- UniSTS:190816

fb66e04.x1 (e-PCR)
- UniSTS:203411

fb66e04 (e-PCR)
- UniSTS:187333

fj87b08.x1 (e-PCR)
- UniSTS:200183

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carboxylesterase 3

Names: carboxylesterase 2

NP_001038401.1

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044936.1 → NP_001038401.1 carboxylesterase 3 precursor

Status: VALIDATED

Source sequence(s)

BX908765, DY571559, EH499836, EH526079

UniProtKB/TrEMBL

A0A8M1N9N2, Q1LUZ9

Related

ENSDARP00000120746.1, ENSDART00000140191.2

Conserved Domains (2) summary

COG0657
Location:122 → 235

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:24 → 535

COesterase; Carboxylesterase family