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slc2a10 solute carrier family 2 member 10 [ Danio rerio (zebrafish) ]

Gene ID: 560546, updated on 4-Jan-2025

Summary

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Official Symbol
slc2a10provided by ZNC
Official Full Name
solute carrier family 2 member 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-6
See related
Ensembl:ENSDARG00000090820 AllianceGenome:ZFIN:ZDB-GENE-080204-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GLUT-10; zgc:171488
Summary
Predicted to enable D-glucose transmembrane transporter activity. Acts upstream of or within circulatory system development and notochord development. Predicted to be located in endomembrane system and perinuclear region of cytoplasm. Predicted to be active in membrane. Is expressed in several structures, including fin; hatching gland; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in arterial tortuosity syndrome. Orthologous to human SLC2A10 (solute carrier family 2 member 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See slc2a10 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (2448779..2456744, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (2344770..2352893)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 Neighboring gene casein kinase 2, alpha 4 polypeptide Neighboring gene si:ch73-267c23.10 Neighboring gene TP53 regulating kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish. Scott GR, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22891320, Free PMC Article
  2. BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment. Boel A, et al. Sci Rep, 2016 Jul 27. PMID 27461955, Free PMC Article
  3. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Chiarelli N, et al. Int J Dev Biol, 2011. PMID 21553381
  4. Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos. Naert T, et al. Sci Rep, 2020 Sep 4. PMID 32887910, Free PMC Article
  5. Expression profile of glucose transport-related genes under chronic and acute exposure to growth hormone in zebrafish. Dalmolin C, et al. Comp Biochem Physiol A Mol Integr Physiol, 2018 Jul. PMID 29530717

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of GLUT10 is associated with impaired cardiovascular system and the notochord and TGFbeta signaling
    Title: GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling.
  2. In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder.
    Title: Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 10
Names
Glut10
glucose transporter type 10
solute carrier family 2 (facilitated glucose transporter), member 10
zglut10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111163.1 → NP_001104633.1  solute carrier family 2, facilitated glucose transporter member 10

    See identical proteins and their annotated locations for NP_001104633.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153938
    UniProtKB/TrEMBL
    A8KB28
    Related
    ENSDARP00000130266.1, ENSDART00000167938.2
    Conserved Domains (2) summary
    cd06174
    Location:10 → 463
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:11 → 479
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    2448779..2456744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172779.5 → XP_005172836.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    UniProtKB/Swiss-Prot
    A8KB28, F1R0H0, I1SV80
    Related
    ENSDARP00000135785.1, ENSDART00000171219.2
    Conserved Domains (1) summary
    cd17436
    Location:8 → 475
    MFS_GLUT10_Class3; Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1R0H0.1 GenPept UniProtKB/Swiss-Prot:F1R0H0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.