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apol1 apolipoprotein L, 1 [ Danio rerio (zebrafish) ]

Gene ID: 560340, updated on 4-Jan-2025

Summary

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Official Symbol
apol1provided by ZNC
Official Full Name
apolipoprotein L, 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3217
See related
Ensembl:ENSDARG00000007425 AllianceGenome:ZFIN:ZDB-GENE-030131-3217
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa95b12; wu:fc30h04; si:rp71-1g18.12
Summary
Predicted to enable lipid binding activity. Acts upstream of or within glomerular filtration; podocyte development; and pronephric glomerulus morphogenesis. Predicted to be located in extracellular region and membrane. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Used to study kidney disease. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1) and APOL4 (apolipoprotein L4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See apol1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37967875..37974727)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37985522..37992399)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cerebellin 14 Neighboring gene cerebellin 9 Neighboring gene apolipoprotein L domain containing 1a Neighboring gene Purkinje cell protein 4 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin. Kotb AM, et al. PLoS One, 2016. PMID 27138898, Free PMC Article
  2. Simultaneous assessment of glomerular filtration and barrier function in live zebrafish. Kotb AM, et al. Am J Physiol Renal Physiol, 2014 Dec 15. PMID 25298528, Free PMC Article
  3. In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. Anderson BR, et al. PLoS Genet, 2015 Jul. PMID 26147622, Free PMC Article
  4. Sequencing and De Novo Assembly of the Gonadal Transcriptome of the Endangered Chinese Sturgeon (Acipenser sinensis). Yue H, et al. PLoS One, 2015. PMID 26030930, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin
    Title: Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular filtration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apolipoprotein L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030138.1 → NP_001025309.1  apolipoprotein L1

    See identical proteins and their annotated locations for NP_001025309.1

    Status: PROVISIONAL

    Source sequence(s)
    AL627248
    UniProtKB/TrEMBL
    Q7T131
    Related
    ENSDARP00000134943.1, ENSDART00000165085.2
    Conserved Domains (1) summary
    pfam05461
    Location:14 → 310
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37967875..37974727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171301.4 → XP_005171358.1  apolipoprotein L1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJ26
    Conserved Domains (1) summary
    pfam05461
    Location:153 → 449
    ApoL; Apolipoprotein L

  2. XM_005171302.4 → XP_005171359.1  apolipoprotein L1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BIK2
    Conserved Domains (1) summary
    pfam05461
    Location:152 → 448
    ApoL; Apolipoprotein L

  3. XM_005171303.4 → XP_005171360.1  apolipoprotein L1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BIK6
    Conserved Domains (1) summary
    pfam05461
    Location:128 → 424
    ApoL; Apolipoprotein L

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    14219..17591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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