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si:dkey-91m11.5 si:dkey-91m11.5 [ Danio rerio (zebrafish) ]

Gene ID: 560226, updated on 9-Dec-2024

Summary

Official Symbol
si:dkey-91m11.5provided by ZNC
Official Full Name
si:dkey-91m11.5provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-932
See related
Ensembl:ENSDARG00000042329 AllianceGenome:ZFIN:ZDB-GENE-060503-932
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction; positive regulation of GTPase activity; and protein phosphorylation. Predicted to be located in axon and dendritic spine. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See si:dkey-91m11.5 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (30500709..30594217)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (30491467..30586647)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene forkhead box D5 Neighboring gene phosphoglucomutase 5 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like a Neighboring gene adenosine A2a receptor a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein
NP_001116725.1
XP_005167231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123253.1NP_001116725.1  PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein

    Status: PROVISIONAL

    Source sequence(s)
    AL845168, CR547121
    UniProtKB/TrEMBL
    A0A8M9Q3H0, A0A8N7UYV0, B0R0B4
    Related
    ENSDARP00000119748.1, ENSDART00000137009.2
    Conserved Domains (5) summary
    cd08686
    Location:9361052
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd04387
    Location:10711271
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13367
    Location:708900
    PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    pfam00621
    Location:530714
    RhoGEF; RhoGEF domain
    pfam09036
    Location:375
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    30500709..30594217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167174.5XP_005167231.1  PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2BEH2, A0A8M9Q3H0
    Conserved Domains (5) summary
    cd08686
    Location:9371053
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd04387
    Location:10721272
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13367
    Location:709901
    PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    pfam00621
    Location:530715
    RhoGEF; RhoGEF domain
    pfam09036
    Location:375
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394731.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    104820..196533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)