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si:dkey-10b15.8 si:dkey-10b15.8 [ Danio rerio (zebrafish) ]

Gene ID: 560031, updated on 4-Jan-2025

Summary

Official Symbol
si:dkey-10b15.8provided by ZNC
Official Full Name
si:dkey-10b15.8provided by ZNC
Primary source
ZFIN:ZDB-GENE-141212-238
See related
Ensembl:ENSDARG00000092625 AllianceGenome:ZFIN:ZDB-GENE-141212-238
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See si:dkey-10b15.8 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (34100628..34104487)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (34156788..34160626)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene serine protease HTRA2, mitochondrial-like Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 144 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 146 Neighboring gene si:busm1-sl7.2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease HTRA2, mitochondrial; si:dkey-33c12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    34100628..34104487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358066.3XP_017213555.1  serine protease HTRA2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1F6, A0A8M9PMS7, F1Q918
    Related
    ENSDARP00000115532.2, ENSDART00000132116.3
    Conserved Domains (2) summary
    cd00987
    Location:102186
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:161
    Trypsin_2; Trypsin-like peptidase domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394793.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    488044..500777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472338.2XP_021328013.1  serine protease HTRA2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M9PLU9, A0A8M9PMS7
    Conserved Domains (1) summary
    cl28339
    Location:1177
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]