U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

arhgef9a Cdc42 guanine nucleotide exchange factor (GEF) 9a [ Danio rerio (zebrafish) ]

Gene ID: 559868, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
arhgef9aprovided by ZNC
Official Full Name
Cdc42 guanine nucleotide exchange factor (GEF) 9aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-271
See related
Ensembl:ENSDARG00000061746 AllianceGenome:ZFIN:ZDB-GENE-070705-271
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arhgef9; si:cu137718.3; si:ch73-92i20.3
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of postsynaptic specialization assembly. Predicted to be active in GABA-ergic synapse; cytosol; and postsynaptic specialization. Is expressed in brain and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See arhgef9a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (21939179..22007059, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (21435379..21497233, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene SNF2 related chromatin remodeling ATPase 1 Neighboring gene uncharacterized LOC137495580 Neighboring gene GRB2 associated binding protein 3 Neighboring gene APC membrane recruitment protein 1 Neighboring gene ankyrin repeat and SOCS box-containing 12a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons. Elbaz I, et al. Mol Neurobiol, 2017 Oct. PMID 27734337
  2. Angiotensin AT2 receptor activates the cyclic-AMP signaling pathway in eel. Wong MK, et al. Mol Cell Endocrinol, 2013 Jan 30. PMID 23174758
  3. The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). Yang S, et al. Int J Biol Macromol, 2023 Jun 1. PMID 37001786
  4. Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Roberto VP, et al. Gene, 2015 Jul 15. PMID 25869932
  5. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of postsynaptic specialization assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho guanine nucleotide exchange factor 9
Names
Cdc42 guanine nucleotide exchange factor (GEF) 9
Cdc42 guanine nucleotide exchange factor a
arhgef9 a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    21939179..22007059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221428.1 → XP_068077529.1  rho guanine nucleotide exchange factor 9 isoform X2

  2. XM_068221427.1 → XP_068077528.1  rho guanine nucleotide exchange factor 9 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASD0

  3. XM_001923406.6 → XP_001923441.1  rho guanine nucleotide exchange factor 9 isoform X4

    UniProtKB/TrEMBL
    A0A1Q1NKP8
    Related
    ENSDARP00000145990.1, ENSDART00000182907.1
    Conserved Domains (3) summary
    cd11975
    Location:7 → 68
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:115 → 294
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:299 → 438
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  4. XM_005165206.5 → XP_005165263.1  rho guanine nucleotide exchange factor 9 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BCL9, E9QHS5
    Related
    ENSDARP00000118893.2, ENSDART00000143878.4
    Conserved Domains (4) summary
    cd11828
    Location:13 → 64
    SH3_ARHGEF9_like; Src homology 3 domain of ARHGEF9-like Rho guanine nucleotide exchange factors
    cd01224
    Location:327 → 466
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:372 → 458
    PH; PH domain
    pfam00621
    Location:143 → 322
    RhoGEF; RhoGEF domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools