prf1.3 perforin 1.3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prf1.3provided by ZNC
Official Full Name: perforin 1.3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-461
See related: Ensembl:ENSDARG00000001572 AllianceGenome:ZFIN:ZDB-GENE-060503-461
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-89b17.6
Summary: Predicted to enable wide pore channel activity. Predicted to be involved in T cell mediated cytotoxicity; defense response to virus; and immunological synapse formation. Predicted to act upstream of or within killing of cells of another organism and leukocyte mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be active in membrane. Is expressed in gill; kidney; and kidney cell. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (5258428..5266748, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (5343059..5348031, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

prf19b, which is mainly produced by myeloid cells, seemed to be involved in antiviral defense, conferring protection after an in vivo infection.
Title: Proinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables pore-forming activity	IEA Inferred from Electronic Annotation more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunological synapse formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within killing of cells of another organism	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte mediated cytotoxicity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: perforin-1.3

Names: perforin 1; perforin 19b; prf19b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317767.1 → NP_001304696.1 perforin-1.3 precursor

Status: PROVISIONAL

Source sequence(s)

KP099718

UniProtKB/TrEMBL

A0A0R8WEP5, F1R8E0

Related

ENSDARP00000001478.6, ENSDART00000001821.8

Conserved Domains (2) summary

cd04032
Location:370 → 497

C2_Perforin; C2 domain of Perforin

pfam01823
Location:137 → 352

MACPF; MAC/Perforin domain