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lman1 lectin, mannose-binding, 1 [ Danio rerio (zebrafish) ]

Gene ID: 559775, updated on 9-Dec-2024

Summary

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Official Symbol
lman1provided by ZNC
Official Full Name
lectin, mannose-binding, 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060201-4
See related
Ensembl:ENSDARG00000069980 AllianceGenome:ZFIN:ZDB-GENE-060201-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc54c09; fi36e01; wu:fc54c09; wu:fi36e01
Summary
Predicted to enable D-mannose binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axis; hatching gland; head; immature eye; and optic primordium. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See lman1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (10702031..10731250)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (10609408..10638557)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Neighboring gene collagen and calcium binding EGF domains 1 Neighboring gene complexin 4a Neighboring gene retinal homeobox gene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development. Zanazzi G, et al. Neural Dev, 2010 Sep 1. PMID 20809954, Free PMC Article
  2. Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Kikuta H, et al. Genome Res, 2007 May. PMID 17387144, Free PMC Article
  3. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article
  4. Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development. Pashay Ahi E, et al. PeerJ, 2016. PMID 27069811, Free PMC Article
  5. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ERGIC-53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386234.1 → NP_001373163.1  protein ERGIC-53 precursor

    Status: VALIDATED

    Source sequence(s)
    BX248399, CU694483
    UniProtKB/TrEMBL
    A0A8N7UQW5
    Related
    ENSDARP00000093080.3, ENSDART00000102304.4
    Conserved Domains (2) summary
    cd06902
    Location:37 → 261
    lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
    COG0419
    Location:276 → 410
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    10702031..10731250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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