xirp2a xin actin binding repeat containing 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xirp2aprovided by ZNC
Official Full Name: xin actin binding repeat containing 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040108-7
See related: Ensembl:ENSDARG00000071113 AllianceGenome:ZFIN:ZDB-GENE-040108-7
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: xirp2; sb:cb1045; wu:fc12g12
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in cell junction. Predicted to colocalize with focal adhesion and stress fiber. Is expressed in several structures, including fin; forebrain; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human XIRP2 (xin actin binding repeat containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10171251..10243037, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (9937035..10007504, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with stress fiber	IBA Inferred from Biological aspect of Ancestor more info

Names: Xin beta6; epithelial protein lost in neoplasm; xin actin-binding repeat containing 2

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_068221888.1 → XP_068077989.1 xin actin-binding repeat-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M9Q058, F8W4U4
XM_005165785.5 → XP_005165842.1 xin actin-binding repeat-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8M2BD29

Conserved Domains (1) summary

pfam08043
Location:951 → 964

Xin; Xin repeat
XM_021477013.2 → XP_021332688.1 xin actin-binding repeat-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M9Q058, F8W4U4

Related

ENSDARP00000124135.1, ENSDART00000148876.2

Conserved Domains (1) summary

pfam08043
Location:952 → 965

Xin; Xin repeat
XM_009302196.4 → XP_009300471.1 xin actin-binding repeat-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A8M3AT61

Conserved Domains (1) summary

pfam08043
Location:820 → 833

Xin; Xin repeat